2942-16-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-Methylbenzothiazole serves as a crucial building block in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides due to its chemical structure and reactivity.
Used as a Flavoring Agent in the Food Industry:
In the food industry, 5-Methylbenzothiazole is utilized as a flavoring agent to impart a distinctive smell and taste to a range of products, enhancing their sensory appeal.
Used in Antimicrobial Research:
5-Methylbenzothiazole has demonstrated antimicrobial properties, making it a candidate for research into new antimicrobial agents to combat resistant strains of bacteria.
Used in Anticancer Research:
5-METHYLBENZOTHIAZOLE's potential anticancer properties position it as a subject of interest for pharmaceutical research, with the aim of developing new treatments for various types of cancer.

InChI:InChI=1/C8H7NS/c1-6-2-3-8-7(4-6)9-5-10-8/h2-5H,1H3

Upstream product

• 35350-31-3 4,4′-dimethyl-2,2′-dinitrodiphenyldisulfide 
• 21303-50-4 2-mercapto-5-methyl benzothiazole 
• 768-11-6 5-bromo-benzthiazole 
• 823-96-1 Trimethylboroxine 
• 14779-17-0 2-amino-5-methylbenzothiazole 
• 13194-69-9 2-iodo-5-methylaniline 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 14779-17-0 2-amino-5-methylbenzothiazole 
• 68867-17-4 1,3-benzothiazole-5-carboxylic acid 
• 57527-88-5 1-(5-Methyl-2-benzothiazolyl)-ethanol 
• 131337-65-0 5-bromomethylbenzothiazole 
• 1415338-18-9 C₁₉H₂₂N₂OS₂ 
• 1415338-20-3 C₁₇H₂₂N₂OS₂ 
• 1569261-60-4 5-methyl-2-(phenylthio)benzo[d]thiazole 
• 1093107-11-9 2-bromo-5-methylbenzothiazole 
• 65840-55-3 1-(5-methylbenzo[d]thiazol-2-yl)ethan-1-one 
• 88-62-0 1-amino-3-methylbenzene-6-sulfonic acid 
• 101084-95-1 5-carboxyl-2-aminobenzothiazole 

Relevant academic research and scientific papers

Iron-catalyzed tandem oxidative coupling and acetal hydrolysis reaction to prepare formylated benzothiazoles and isoquinolines

The aldehyde group is one of the most versatile intermediates in synthetic chemistry, and the introduction of an aldehyde group into heteroarenes is important for the transformation of molecular structure. Herein, we achieved the direct formylation of benzothiazo/les and isoquinolines. The reaction features a novel iron-catalyzed Minisci-type oxidative coupling process using commercially available 1,3-dioxolane as a formylated reagent followed by acetal hydrolysis without a separation process. The reaction can be performed under exceedingly mild reaction conditions and exhibits broad functional group tolerance.

K2S as Sulfur Source and DMSO as Carbon Source for the Synthesis of 2-Unsubstituted Benzothiazoles

We describe a three-component reaction of o-iodoanilines with K2S and DMSO that provides 2-unsubstituted benzothiazoles in moderate to good isolated yields with good functional group tolerance. Electron-rich aromatic amines and o-phenylenediamines instead of o-iodoanilines provided 2-unsubstituted benzothiazoles and 2-unsubstituted benzimidazoles with and without K2S under similar conditions. Notably, DMSO plays three vital roles: carbon source, solvent, and oxidant.

Synthetic method of ammonium acetate-mediated benzothiazole compound

The invention discloses a synthetic method of an ammonium acetate-mediated benzothiazole compound . The synthetic method comprises the steps: adding an o-haloaniline derivative, potassium sulfide, dimethyl sulfoxide, a catalyst, an additive 1 and an additive 2 into a reaction tube, carrying out a stirring reaction at the temperature of 130-150 DEG C, cooling to room temperature after the reactionis finished, and separating and purifying the product to obtain the benzothiazole compound. The invention provides the synthetic method of the benzothiazole compound by taking K2S as a sulfur source,DMSO as a carbon source and an oxidizing agent, an o-haloaniline derivative as a substrate and an ammonium acetate mediated three-component one-pot method. The method has the advantages of fewer reaction steps, mild reaction conditions, good functional group tolerance and the like.

Method for synthesizing benzothiazole by microwave radiation of benzothioamide compound in aqueous phase

The invention discloses a method for synthesizing benzothiazole by microwave radiation of a benzothioamide compound in an aqueous phase. The method includes the steps: adding the benzothioamide compound into the aqueous phase under microwave conditions; performing cyclization under alkaline conditions to generate the benzothiazole. The method for preparing the benzothiazole is environmentally friendly, simple and convenient in operation, safe, cheap and efficient. Compared with the prior art, the method is applicable to a lot of functional groups, high in yield, few in by-products, simple in operation, safe, low in cost and environmentally friendly.

AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.