1415388-32-7

Basic information

• Product Name: C₂₀H₁₇N₃O₃
• Synonyms: C₂₀H₁₇N₃O₃
• CAS NO: 1415388-32-7
• Molecular Weight: 347.373
• Mol File: 1415388-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₇N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₇N₃O₃(1415388-32-7)
• EPA Substance Registry System: C₂₀H₁₇N₃O₃(1415388-32-7)

Safety Data

• Hazardous Substances Data: 1415388-32-7(Hazardous Substances Data)

Upstream product

• 2587-00-0 2,6-dichloropyridine N-oxide 
• 1415388-29-2 C₅H₄BCl₂NO₃ 
• 1415388-30-5 C₁₁H₇Cl₂NO 
• 754214-56-7 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1415388-31-6 C₁₃H₁₂ClNO₃ 

Downstream Products

• 1415388-33-8 C₂₄H₂₅N₃O₄ 

Relevant articles and documents

Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase i inhibitors

We conducted a high throughput screening for glyoxalase I (GLO1) inhibitors and identified 4,6-diphenyl-N-hydroxypyridone as a lead compound. Using a binding model of the lead and public X-ray coordinates of GLO1 enzymes complexed with glutathione analogues, we designed 4-(7-azaindole)-substituted 6-phenyl-N-hydroxypyridones. 7-Azaindole's 7-nitrogen was expected to interact with a water network, resulting in an interaction with the protein. We validated this inhibitor design by comparing its structure-activity relationship (SAR) with that of corresponding indole derivatives, by analyzing the binding mode with X-ray crystallography and by evaluating its thermodynamic binding parameters.