1415476-91-3Relevant academic research and scientific papers
Triphenylamine/carbazole-modified ruthenium(ii) Schiff base compounds: Synthesis, biological activity and organelle targeting
Chen, Shujiao,Ge, Xingxing,Huang, Jie,Liu, Tong,Liu, Xicheng,Liu, Zhe,Shao, Yue,Tian, Laijin,Wang, Qinghui,Yao, Meimei,Yuan, Xiang-Ai
, p. 8774 - 8784 (2020)
Four triphenylamine/carbazole-modified half-sandwich ruthenium(ii) compounds [(η6-p-cymene)Ru(N/O^N)Cl]0/+ with Schiff base chelating ligands (N/O^N) are synthesized and characterized. The introduction of Schiff base units effectively increases the antitumor activity of these compounds (IC50: 1.70 ± 0.56-17.75 ± 3.10 μM), which, meanwhile, can inhibit the metastasis of tumor cells effectively. These compounds follow an energy-dependent cellular uptake mechanism, mainly accumulate in lysosomes to destroy their integrity, and then eventually promote apoptosis. In addition, these compounds can induce an increase of intracellular reactive oxygen species (ROS) levels and provide an antitumor mechanism of oxidation, which is confirmed by the decrease of mitochondrial membrane potential (MMP) and the catalytic oxidation of the coenzyme nicotinamide-adenine dinucleotide (NADH). All these indicate that these ruthenium(ii) compounds are expected to be dual-functional antitumor agents: anti-metastasis and lysosomal damage.
Preparation and antitumor application of: N -phenylcarbazole/triphenylamine-modified fluorescent half-sandwich iridium(iii) Schiff base complexes
Cui, Wen,Hu, Fenglian,Huang, Chenyang,Li, Jingwen,Li, Yiqing,Liu, Xicheng,Liu, Zhe,Wang, Liyan,Yuan, Xiang-Ai,Zong, Jiawen
supporting information, p. 15888 - 15899 (2021/12/02)
Four N-phenylcarbazole/triphenylamine-appended half-sandwich iridium(iii) salicylaldehyde Schiff base complexes ([(?5-Cpx)Ir(O^N)Cl]) were prepared and characterized. The complexes exhibited similar antitumor activity to cisplatin and effectively inhibite
A novel class of Zn(II) Schiff base complexes with aggregation-induced emission enhancement (AIEE) properties: Synthesis, characterization and photophysical/electrochemical properties
Xie, Yu-Zhong,Shan, Guo-Gang,Li, Peng,Zhou, Zi-Yan,Su, Zhong-Min
, p. 467 - 474 (2013/02/23)
A series of novel Zn(II) Schiff base complexes with diphenylamino and carbazole groups that exhibited aggregation-induced emission enhancement were designed and synthesized. The properties of four complexes were investigated by UV-Vis absorption and fluorescence emission spectroscopy, cyclic voltammetry and density functional theory calculations. The fluorescence intensities of the four dyes are weak in tetrahydrofuran, but become strong in a mixture of water/tetrahydrofuran (v/v = 9/1). This work constitutes the first observation of this phenomenon for Zn(II) Schiff base complexes. A simple model complex, without the possibility of intramolecular rotational motion, was prepared in order to determine the mechanism of the AIEE. The present aggregation-induced emission enhancement was attributed to restricted intramolecular rotational motions in the solid by carefully analyzing the difference in molecular structure and photophysical properties amongst the new complexes.
