1415480-75-9Relevant academic research and scientific papers
A concise synthesis of enantiomerically pure aroyl-l-alanines and dihydroaroyl-l-alanines
Gardianova, Maria,Slizik, Lubos,Korenova, Anna,Povazanec, Frantisek,Berkes, Dusan
, p. 92 - 100 (2012/10/29)
Straightforward preparation of enantiomerically highly enriched N-substituted aroylalanines has been developed. This process involves the combination of crystallization-induced asymmetric transformation and a conjugate addition of N-nucleophiles to the corresponding aroylacrylic acids. Further transformations to 3,4-dichlorobenzoylalanine and aroyl-l-alanines via periodate oxidation and stereoselective reduction to N-substituted syn-4-aryl-4-hydroxy- 2-aminobutanoic acids are also described.
