63104-97-2

Usage

Uses

Used in Pharmaceutical Industry:
(E)-4-(4-NITROPHENYL)-4-OXOBUT-2-ENOIC ACID is used as an intermediate compound for the synthesis of various pharmaceuticals and organic compounds. Its potential antibacterial and antifungal properties make it a promising candidate for the development of new drugs and medications.
Used in Dye and Pigment Industry:
(E)-4-(4-NITROPHENYL)-4-OXOBUT-2-ENOIC ACID is used as a colorant in the production of dyes and pigments due to its vibrant yellow color. Its chemical properties allow it to be a valuable ingredient in creating a wide range of colors for various applications.

Upstream product

• 4974-57-6 4-nitrophenylglyoxal 
• 141-82-2 malonic acid 
• 100-19-6 (4-nitrophenyl)ethanone 
• 563-96-2 2,2-dihydroxyacetic acid 
• 6000-59-5 glyoxalic acid monohydrate 

Downstream Products

• 813430-47-6 methyl (4R,5R)-5-methoxy-4-[(E)-4-(4-nitrophenyl)-4-oxobut-2-enoyloxy]-4,5-dihydrofuran-2-carboxylate 
• 871566-25-5 {[(2R,2aR,4aR,6R,7aS,7bS)-6-(4-Amino-phenyl)-2-methoxy-4-oxo-hexahydro-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid 
• 871566-23-3 {[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester 
• 1415480-66-8 C₁₈H₂₀N₂O₆ 
• 1415480-54-4 C₁₉H₂₀N₂O₆ 
• 1415480-70-4 C₁₉H₂₂N₂O₆ 
• 1415480-75-9 C₁₀H₁₀N₂O₅ 
• 1579957-73-5 C₁₂H₁₁NO₆ 
• 131504-53-5 ethyl (E)-4-(4-nitrophenyl)-4-oxo-2-butenoate 
• 1579957-87-1 C₁₂H₉NO₆ 

Relevant academic research and scientific papers

Hydrogen-bond-directed formal [5 + 1] annulations of oxindoles with ester-linked bisenones: Facile access to chiral spirooxindole δ-lactones

A novel bifunctional thiourea catalyzed formal [5 + 1] cycloaddition of oxindoles and ester-linked bisenones was successfully developed. This strategy involves two sequential Michael additions, leading to spirooxindole δ-lactones with three contiguous ste

Gastric anti-secretory, anti-ulcer and cytoprotective properties of substituted (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic acids

A class of anti-secretory, anti-ulcer and cytoprotective agents, the substituted (E)-4-phenyl and heteroaryl-4-oxo-2-butenoic acids, is described.This chemical structure is not related to those of any known anti-cholinergic drugs, histamine H2-receptor antagonists or prostaglandins.Five compounds, 4-(2-methoxyphenyl)- 15, 4-(4-methoxyphenyl)- 22, 4-(3,4-dimethoxyphenyl)- 32, 4-(3,4,5-trimethoxyphenyl)- 40, and 4-(2-furanyl)-4-oxo-2-butenoic acid 44, have cytoprotective activity at a very low dose (0.6 mg/kg, p.o.) and anti-secretory and anti-ulcer activities at higher doses.One of these compounds, RU 38086 40, has been selected for clinical evaluation.Keywords - anti-ulcer agents / cytoprotective agents / (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic acids.