1415560-99-4Relevant academic research and scientific papers
Synthesis of 5-halogenated 1,2,3-triazoles under stoichiometric Cu(I)-mediated azide-alkyne cycloaddition (CuAAC or 'Click Chemistry')
Goyard, David,Praly, Jean-Pierre,Vidal, Sébastien
, p. 79 - 83 (2012)
Glucosylated heterocycles have been identified as potent inhibitors of glycogen phosphorylase (GP), a biomolecular target for the treatment of hyperglycemia and therefore type 2 diabetes. Several glucosylated triazoles have been evaluated as GP inhibitors
Efficient atropodiastereoselective access to 5,5′-bis-1,2,3- triazoles: Studies on 1-glucosylated 5-halogeno 1,2,3-triazoles and their 5-substituted derivatives as glycogen phosphorylase inhibitors
Goyard, David,Chajistamatiou, Aikaterini S.,Sotiropoulou, Anastasia I.,Chrysina, Evangelia D.,Praly, Jean-Pierre,Vidal, Sebastien
supporting information, p. 5423 - 5432 (2014/05/20)
Whereas copper-catalyzed azide-alkyne cycloaddition (CuAAC) between acetylated β-D-glucosyl azide and alkyl or phenyl acetylenes led to the corresponding 4-substituted 1-glucosyl-1,2,3-triazoles in good yields, use of similar conditions but with 2 equiv C
Synthesis of 5-halogenated 1,2,3-triazoles under stoichiometric Cu(I)-mediated azide-alkyne cycloaddition (CuAAC or 'Click Chemistry')
Goyard, David,Praly, Jean-Pierre,Vidal, Sebastien
, p. 79 - 83,5 (2012/12/12)
Glucosylated heterocycles have been identified as potent inhibitors of glycogen phosphorylase (GP), a biomolecular target for the treatment of hyperglycemia and therefore type 2 diabetes. Several glucosylated triazoles have been evaluated as GP inhibitors
