1415565-65-9

Upstream product

• 130879-25-3 3,5-dichloro-2-(4-methoxy-phenyl)pyrazin-2-(1H)-one 
• 2450-71-7 Propargylamine 

Downstream Products

• 1415565-55-7 5-chloro-7-(4-methoxyphenyl)-3-methylimidazo[1,2-a]pyrazin-8(7H)-one 
• 1415565-74-0 C₁₄H₁₂ClN₃O₂ 
• 1415565-75-1 7-(4-methoxyphenyl)-3-methyl-5-p-tolylimidazo[1,2-a]pyrazin-8(7H)-one 
• 1415565-76-2 7-(4-methoxyphenyl)-3-methyl-5-phenylimidazo[1,2-a]pyrazin-8(7H)-one 
• 1451179-11-5 7-(4-methoxyphenyl)-8-oxo-5-(p-tolyl)-7,8-dihydroimidazo[1,2-a]-pyrazine-3-carbaldehyde 
• 1451179-12-6 3-[bis(4-methoxyphenyl)methylene]-5,7-bis(4-methoxyphenyl)-2,3-dihydroimidazo[1,2-a]pyrazin-8(7H)-one 
• 1451178-97-4 5-chloro-1-(4-methoxyphenyl)-3-(3-phenylprop-2-ynylamino)-pyrazin-2(1H)-one 
• 1451178-99-6 5-chloro-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenyl)prop-2-ynylamino]pyrazin-2(1H)-one 
• 1451179-05-7 5-chloro-7-(4-methoxyphenyl)-3-(morpholinomethyl)imidazo-[1,2-a]pyrazin-8(7H)-one 
• 1451179-07-9 5-chloro-7-(4-methoxyphenyl)-3-(pyrrolidin-1-ylmethyl)imidazo-[1,2-a]pyrazin-8(7H)-one 
• 1451179-06-8 5-chloro-7-(4-methoxyphenyl)-3-(piperidin-1-ylmethyl)imidazo-[1,2-a]pyrazin-8(7H)-one 
• 1451179-08-0 5-(4-ethoxyphenyl)-7-(4-methoxyphenyl)-8-oxo-7,8-dihydroimidazo[1,2-a]pyrazine-3-carbaldehyde 
• 1451179-03-5 (E)-5-chloro-3-[iodo(4-methoxyphenyl)methylene]-7-(4-methoxyphenyl)-2,3-dihydroimidazo[1,2-a]pyrazin-8(7H)-one 
• 1451179-00-2 (E)-5-chloro-3-[iodo(phenyl)methylene]-7-(4-methoxyphenyl)-2,3-dihydroimidazo[1,2-a]pyrazin-8(7H)-one 

Relevant academic research and scientific papers

A facile diversity-oriented synthesis of imidazo[1,2-a]pyrazinones via gold-catalyzed regioselective heteroannulation of propynylaminopyrazinones

A gold-catalyzed regioselective heteroannulation strategy has been developed for the concise and efficient synthesis of imidazo[1,2-a]pyrazinones. The protocol allows the introduction of diversity via the application of substituted propargyl amines or via Suzuki-coupling of the generated imidazo[1,2-a]pyrazinones with various (het)aryl boronic acids.

Diversely substituted imidazo[1,2-a]pyrazine-8-oxo-3-carbaldehydes: An iodine-mediated cyclization/oxidation approach

A mild and efficient iodine-mediated intramolecular heteroannulation approach for the construction of the imidazo[1,2-a]pyrazinone core has been developed. Under ambient conditions, this metal-free protocol allows easy access to densely functionalized imidazo[1,2-a]pyrazinone-3-carbaldehydes or (aminomethyl)imidazo[1,2-a]pyrazinones from substrates containing terminal alkynes by cyclization and subsequent oxidation or amination. Further diversification may be introduced by using substrates containing an internal alkyne and/or Suzuki coupling after cyclization to generate polysubstituted (dihydro)imidazo[1,2-a]pyrazinones. An iodine-mediated heteroannulation approach for the construction of (dihydro)imidazo[1,2-a]pyrazinone motifs have been developed. For terminal alkynes, a hydrolysis/oxidation sequence or an amination gives direct access to imidazo[1,2-a]pyrazin-3-carbaldehydes or aminomethyl-imidazo-[1,2-a]pyrazinones in a one-pot process. Copyright