1415570-83-0Relevant academic research and scientific papers
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)
Yu, Yang,Wu, Zhicai,Shi, Zhi-Cai,He, Shuwen,Lai, Zhong,Cernak, Timothy A.,Vachal, Petr,Liu, Min,Liu, Jian,Hong, Qingmei,Jian, Tianying,Guiadeen, Deodial,Krikorian, Arto,Sperbeck, Donald M.,Verras, Andreas,Sonatore, Lisa M.,Murphy, Beth A.,Wiltsie, Judyann,Chung, Christine C.,Gorski, Judith N.,Liu, Jinqi,Xiao, Jianying,Wolff, Michael,Tong, Sharon X.,Madeira, Maria,Karanam, Bindhu V.,Shen, Dong-Ming,Balkovec, James M.,De Vita, Robert J.,Pinto, Shirly,Nargund, Ravi P.
, p. 1380 - 1385 (2019)
The parallel medicinal chemistry (PMC) was effectively applied to accelerate the optimization of diacylglycerol O-acyltransferase I (DGAT-1) inhibitors. Through a highly collaborative and iterative library design, synthesis and testing, a benzimidazole lead was rapidly and systematically advanced to a highly potent, selective and bioavailable DGAT1 inhibitor with the potential for further development.
