1415580-99-2

Upstream product

• 71904-80-8 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylic acid 
• 182120-82-7 2-(tert-butoxycarbonylaminomethyl)-1,3-thiazole-4-carboxamide 
• 251294-64-1 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile 
• 1415580-91-4 tert-butyl ((4-(2H-tetrazol-5-yl)thiazol-2-yl)methyl)carbamate 
• 1415580-93-6 methyl 2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-1H-tetrazol-1-yl)acetate 
• 96929-05-4 ethyl 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carboxylate 

Relevant academic research and scientific papers

Biological evaluation of new largazole analogues: Alteration of macrocyclic scaffold with click chemistry

We report the design, synthesis, and biological evaluation of a new series of largazole analogues in which a 4-methylthiazoline moiety was replaced with a triazole and tetrazole ring, respectively. Compound 7 bearing a tetrazole ring was identified to show much better selectivity for HDAC1 over HDAC9 than largazole (10-fold). This work could serve as a foundation for further exploration of selective HDAC inhibitors using a largazole molecular scaffold.