96929-05-4

Usage

Uses

Used in Agricultural Applications:
Tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate is used as an insecticide and acaricide for controlling a wide range of pests in various crops. Its application is crucial for protecting plants from damage caused by mites, aphids, and whiteflies, ensuring healthier growth and higher yields.
The use of this chemical in agriculture is aimed at:
Preventing infestations that can lead to significant crop losses.
Providing a targeted approach to pest control, reducing the need for broader, potentially more harmful treatments.
Ensuring the effective management of pests resistant to other classes of pesticides.
However, due to its potential harmful effects on humans and non-target organisms, it is imperative that this chemical is handled and applied with the utmost care, adhering to safety guidelines and regulations to minimize risks to the environment and human health.

InChI:InChI=1/C12H18N2O4S/c1-5-17-10(15)8-7-19-9(14-8)6-13-11(16)18-12(2,3)4/h7H,5-6H2,1-4H3,(H,13,16)

Upstream product

• 31954-27-5 N-(tert-butoxycarbonyl)glycine methyl ester 

Downstream Products

• 71904-80-8 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylic acid 
• 1043577-34-9 (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-((R)-2'-(((tert-butoxycarbonyl)amino)methyl)-4-methyl-4,5-dihydro[2,4'-bithiazole]-4-carboxamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate 
• 871715-99-0 C₂₉H₃₁N₃O₆S 
• 871715-98-9 C₁₁H₁₂N₂S*ClH 
• 871715-97-8 tert-butyl N-[(4-benzylthiazol-2-yl)methyl]carbamate 
• 203793-16-2 2-(aminomethyl)thiazole-4-carboxamide 
• 1415580-99-2 C₃₈H₃₉N₇O₄S₂ 
• 1415580-98-1 (9S,12S)-9-isopropyl-12-((E)-4-(tritylthio)but-1-en-1-yl)-11-oxa-18-thia-3,4,5,8,15,20,21-heptaazatricyclo[15.2.1.1^2,5]henicosa-1⁽¹⁹⁾,2⁽²¹⁾,3,17⁽²⁰⁾-tetraene-7,10,14-trione 
• 1415580-95-8 (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(5-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-2H-tetrazol-2-yl)acetamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate 
• 1415580-94-7 (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-(2-(4-(2-(((tert-butoxycarbonyl)amino)methyl)thiazol-4-yl)-1H-1,2,3-triazol-1-yl)acetamido)-3-methylbutanoyl)oxy)-7-S₁₁(tritylthio)hept-4-enoate 
• 91711-96-5 2-Aminomethyl₄-thiazolcarbonsaeure-ethylester 
• 186453-48-5 2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester 

Relevant academic research and scientific papers

RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles

The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. Herein we investigate the effect of using thiazoles as the backbone in RITA-like molecules and modifying the terminal groups of these trithiazoles, thereby generating 41 unique structures. Incorporating side chains with varied steric bulk allowed us to investigate how size and a stereocenter impacted biological activity. Subjecting compounds to growth inhibition assays on HCT-116 cells showed that the most potent compounds 7d, 7e, and 7h had GI50 values of 4.4, 4.4, and 3.4 μM, respectively, versus RITA (GI50 of 800 nM). Analysis of these compounds in apoptosis assays proved that 7d, 7e, and 7h were as effective as RITA at inducing apoptosis. Evaluating the impact of 7h on proteins targeted by RITA (p53, c-Myc, and Mcl-1) indicated that it acts via a different mechanism of action to that of RITA. RITA suppressed Mcl-1 protein via p53, whereas compound 7h suppressed Mcl-1 expression via an alternative mechanism independent of p53.