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Upstream product

• 123-91-1 1,4-dioxane 
• 100-42-5 styrene 
• 102-96-5 (2-nitroethenyl)benzene 
• 637-44-5 phenylpropyolic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 536-74-3 phenylacetylene 

Relevant academic research and scientific papers

Visible-Light-Mediated Oxidative Decarboxylative Coupling of Cinnamic Acid Derivatives with Tetrahydrofuran

A visible-light-mediated protocol for direct oxidative decarboxylative coupling of various cinnamic acid derivatives with tetrahydrofuran was developed, leading to simple preparations of a range of vinyltetrahydrofurans under operationally mild and conven

Photoredox Oxo-C(sp3)-H Bond Functionalization via in Situ Cu(I)-Acetylide Catalysis

A unified strategy for the synthesis of 2-vinyl heterocycles is reported. With visible light irradiation, simple and cheap CuCl is able to functionalize a terminal alkyne, giving Cu(I)-acetylide in situ. Unlike the case of noble metals or organic dye photocatalysts, this critical Cu(I)-acetylide not only activates the C-H bond of terminal alkynes but also serves as a photocatalyst to achieve varieties of 2-vinyl heterocycles in good to excellent yields, even for large scale and late-stage functionalization of natural product.

Visible Light Mediated C(sp3)-H Alkenylation of Cyclic Ethers Enabled by Aryl Ketone

C?H alkenylation of cyclic ethers (THF, 1,4-dioxane) using the readily available nitroalkenes as the alkenylating reagents has been developed. It allows the rapid access to the α-alkenyl ethers with high E-selectivity. The previous inaccessible α-dienyl e

NiCl2-catalyzed radical cross decarboxylative coupling between arylpropiolic acids and cyclic ethers

A direct alkenylation of cyclic ethers via radical cross decarboxylative coupling process catalyzed by NiCl2 and using DTBP as radical initiator and oxidant was developed. A variety of arylpropiolic acids and cyclic ethers were transformed into the corresponding 2-arylvinyl cyclic ethers in moderate to excellent yields. Mechanistic experiments were conducted to determine the nature of the reaction intermediates, and a plausible reaction mechanism involving NiCl2-promoted radical process was proposed.

Silver-catalyzed decarboxylative C(sp2)-C(sp3) coupling reactions: Via a radical mechanism

A silver catalyzed decarboxylative C(sp2)-C(sp3) coupling of vinylic carboxylic acids with alcohols, alkylbenzenes, cycloalkanes and cyclic ethers was developed by using DTBP as an oxidant. This reaction tolerates a wide range of substrates, and products are obtained in good to excellent yields. The reaction also shows good stereoselectivity, and only trans-isomers are obtained. In addition, a radical pathway would be involved to facilitate this decarboxylative C(sp2)-C(sp3) coupling reaction.

Copper porphyrin catalyzed esterification of C(sp3)-H via a cross-dehydrogenative coupling reaction

The crystal structure of 5,10,15,20-tetra(ethoxycarbonyl)porphyrin copper(ii) showed that its central copper has a six-coordinate structure. An efficient copper porphyrin-catalyzed cross-dehydrogenative coupling (CDC) esterification reaction between C(sp

Rhenium-catalyzed dehydrogenative olefination of C(sp3)-H bonds with hypervalent iodine(III) reagents

A dehydrogenative olefination of C(sp3)-H bonds is disclosed here, by merging rhenium catalysis with an alanine-derived hypervalent iodine(iii) reagent. Thus, cyclic and acyclic ethers, toluene derivatives, cycloalkanes, and nitriles are all successfully alkenylated in a regio- and stereoselective manner.

Iron-catalyzed alkenylation of cyclic ethers via decarboxylative sp 3(C)-sp2(C) coupling

An efficient Fe(acac)3-catalyzed decarboxylative C(sp 2)-C(sp3) coupling reaction via oxidation of C-H bond adjacent to an oxygen atom has been developed successfully, in which cyclic ethers are selectively transformed into the corresponding alkenylation products with good chemical yields and excellent stereoselectivities. The mechanism was studied and the reaction was supposed to proceed through a radical oxidative coupling process.

Copper catalyzed cross-coupling reactions of carboxylic acids: An expedient route to amides, 5-substituted γ-lactams and α-acyloxy esters

A convenient and recyclable catalytic protocol for the synthesis of N,N-dimethyl substituted amides, 5-substituted γ-lactams and α-acyloxy ethers from carboxylic acids using CuO nanoparticles and TBHP is described.

Dirhodium caprolactamate catalyzed alkoxyalkylation of terminal alkynes

Dirhodium caprolactamate [Rh2(cap)4] effectively catalyzes alkoxyalkylation of terminal alkynes in the presence of tert-butyl hydroperoxide (TBHP) under mild conditions. Georg Thieme Verlag Stuttgart New York.