1415641-77-8Relevant academic research and scientific papers
Synthesis of Pyrido[1,2-a]benzimidazoles by Electroreductive Heterocyclization of 1-(2-nitroaryl)pyridinium Chlorides
Sokolov, Aleksandr A.,Syroeshkin, Mikhail A.,Begunov, Roman S.,Rusakova, Nadezhda N.,Gultyai, Vadim P.
, p. 312 - 313 (2012)
The electrochemical reduction of N-(2-nitro-4-R-phenyl)pyridinium chlorides (R = CF3, CN, CO2Et) at a lead cathode in HCl/Pr iOH/H2O affords the corresponding 7-R-pyrido[1,2-a] benzimidazoles in 70-94% yields.
Efficient electrochemical synthesis of pyrido[1,2-a]benzimidazoles
Sokolov,Syroeshkin,Solkan,Shebunina,Begunov,Mikhal'Chenko,Leonova,Gultyai
, p. 372 - 380 (2015/02/05)
Electrochemical reduction of N-(2-nitroaryl)pyridinium chlorides in alcohol - dilute HCl mixtures gave pyrido[1,2-a]benzimidazoles in high yields in both divided and undivided cells. According to cyclic voltammetry measurements and DFT calculations (B3LYP/6-31+G(d)), the reaction involves intermediate formation of the corresponding hydroxylamine derivative followed by its heterocyclization.
