1415652-34-4

Basic information

• Product Name: C₄₇H₇₀N₃O₅
• Synonyms: C₄₇H₇₀N₃O₅
• CAS NO: 1415652-34-4
• Molecular Weight: 757.09
• Mol File: 1415652-34-4.mol

Chemical Properties

• CAS DataBase Reference: C₄₇H₇₀N₃O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₇H₇₀N₃O₅(1415652-34-4)
• EPA Substance Registry System: C₄₇H₇₀N₃O₅(1415652-34-4)

Safety Data

• Hazardous Substances Data: 1415652-34-4(Hazardous Substances Data)

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 471-53-4 enoxolone 
• 51298-47-6 N-(L-phenylalanine)-3β-hydroxy-11-oxo-olean-12-en-18β-H-30-amide 
• 34272-83-8 2,2,5,5-tetramethyl-3-aminopyrrolidine-1-oxyl 

Relevant articles and documents

Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives

Eighteen novel spin-labeled 18β-glycyrrhetinic acid (GA) derivatives were designed, synthesized, and evaluated for cytotoxicity against four human tumor cell lines (A-549, DU-145, KB and KBvin). Most of the derivatives showed more significant cytotoxicity than that of the parent compound GA. The best compound, 6j, with a tryptophan amino moiety and piperidine nitroxyl radical showed GI50 values of 13.7-15.0 μM, and was fivefold more potent than GA. In a mechanism of action study, compound 7a was confirmed as a 20S proteasome inhibitor in both in vitro and cell-based assays. These findings support further optimization efforts based on 18β-GA as a lead compound to develop potential anticancer drug candidates.