1415656-15-3

Upstream product

• 1415656-14-2 (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline 
• 95592-67-9 4-pivaloyloxybenzaldehyde 
• 1415656-13-1 (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline 

Downstream Products

• 1415656-16-4 C₃₃H₄₅NO₇ 
• 1415656-17-5 C₂₈H₃₇NO₅ 
• 129724-55-6 (+)-colchiethanamine 
• 1415656-18-6 C₂₉H₃₉NO₅ 

Relevant academic research and scientific papers

Synthesis of the 1-phenethyltetrahydroisoquinoline alkaloids (+)-dysoxyline, (+)-colchiethanamine, and (+)-colchiethine

Asymmetric total syntheses of the 1-phenethyl-1,2,3,4- tetrahydroisoquinoline alkaloids (+)-dysoxyline (1), (+)-colchiethanamine (2), and (+)-colchiethine (3) are described. In the synthetic routes, coupling of a key, enatiomerically pure 1-(sulfonylmethyl)tetrahydroisoquinoline with aromatic aldehydes, performed by using the Julia-Kocienski reaction, afforded the corresponding 1-(β-styryl)-substituted tetrahydroisoquinolines with complete retention of the absolute configuration at the C1 carbon atom. Functionalization of the products generated in these processes by using four-or five-step sequences gave the target alkaloids 1-3.