1415662-85-9Relevant academic research and scientific papers
An efficient ultrasound promoted one-pot three-component synthesis and antibacterial activities of novel pyrimido[4,5-b]quinoline- 4,6(3H,5H,7H,10H)- dione derivatives
Jourshari, Maryam S.,Mamaghani, Manouchehr,Tabatabaeian, Khalil,Shirini, Farhad,Rassa, Mehdi,Langhari, Hadiss
, p. 664 - 670 (2013/02/23)
A series of novel pyrimido[4,5-b]quinoline-4,6(3H,5H,7H,10H)-dione derivatives was synthesized by one-pot three-component reaction of the appropriate aldehyde, dimedone or cyclohexanedione and 6-aminothiouracil in ethanol under ultrasonic irradiation at 50 oC in short reaction times (1.5-3 min) and excellent yields (94-99%). The antibacterial activities of the synthesized compounds were evaluated on M. leuteus, B. subtilis, E. coli and Ps. aeruginosa. All the synthesized products showed good antibacterial activities.
