1074-41-5

Basic information

• Product Name: 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL
• Synonyms: 4-Amino-2-(methylthio)-6-pyrimidinol ,97%;4-pyrimidinol, 6-amino-2-(methylthio)-;4-Amino-2-(methylthio)-6-pyrimidinol;6-amino-2-(methylthio)-1H-pyrimidin-4-one;6-amino-2-methylsulfanyl-1H-pyrimidin-4-one;6-azanyl-2-methylsulfanyl-1H-pyrimidin-4-one;4-Amino-2-(methylthio)-6-pyrimidinol ,98%;4-AMino-6-hydroxy-2-(Methylthio)pyriMidine
• CAS NO: 1074-41-5
• Molecular Formula: C₅H₇N₃OS
• Molecular Weight: 157.2
• Product Categories: Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds;Intermediates
• Mol File: 1074-41-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 271-273°C (dec.)
• Boiling Point: 285.209 °C at 760 mmHg
• Flash Point: 126.29 °C
• Appearance: White solid
• Density: 1.549 g/cm³
• Vapor Pressure: 0.00284mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: Refrigerator
• PKA: 8.82±0.50(Predicted)
• CAS DataBase Reference: 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL(1074-41-5)
• EPA Substance Registry System: 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL(1074-41-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 1074-41-5(Hazardous Substances Data)

Usage

Chemical Properties

4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL is White Solid

Uses

Different sources of media describe the Uses of 1074-41-5 differently. You can refer to the following data:
1. 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL is a useful synthetic intermediate
2. Intermediate in the preparation of certain antibiotics

InChI:InChI=1/C5H7N3OS/c1-10-5-7-3(6)2-4(9)8-5/h2H,1H3,(H3,6,7,8,9)

Upstream product

• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 1004-40-6 4-aminothiouracil 
• 65802-56-4 4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate 
• 17356-08-0 thiourea 
• 105-56-6 ethyl 2-cyanoacetate 
• 1004-40-6 6-Amino-2-thiouracil 
• 1004-40-6 6-amino-2-thioxo-1,2-dihydro-4(3H)-pyrimidinone 
• 74-83-9 methyl bromide 

Downstream Products

• 5446-89-9 2-methylsulfanyl-1,7⁽⁹⁾-dihydro-purin-6-one 
• 1005-38-5 4-amino-6-chloro-2-methylthiopyrimidine 
• 104637-63-0 6-amino-2-(morpholin-4'-yl)pyrimidin-4(3H)-one 
• 33080-87-4 6-amino-2-(4'-methylpiperazin-1'-yl)ptrimidin-4(3H)-one 
• 54030-56-7 6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one 
• 3289-53-0 6-methoxy-2-methylsulfanyl-pyrimidin-4-ylamine 
• 1178896-28-0 toluene-4-sulfonic acid 6-amino-2-methylsulfanylpyrimidin-4-yl ester 
• 1253375-32-4 5-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-2-(methylsulfanyl)-6-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one 
• 1253375-36-8 C₂₁H₂₀ClN₃O₃S 
• 1314704-89-6 2-methylthio-4-phenethylamino-6-propylthiopyrimidine 
• 1314704-90-9 2-methylthio-4-(1-phenylethyl)amino-6-propylthiopyrimidine 
• 43005-49-8 4-amino-6-hydroxy-2-methylthio-5-nitrosopyrimidine 

Relevant articles and documents

Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents

Abstract: 7-aminopyrimidin-5(1H)-one (5) was utilized as a starting material for the preparation of new, Schiff bases (13–19), amides 23, 24, imide 25, as well as thiourea derivatives 30–33 incorporating the triazolopyrimidines nucleus in their molecules. Structural elucidations for the new compounds were based upon compatible microanalytical and spectroscopic measurement. Biological evaluation indicated that compounds 23, 31, 33, 32, and 30 possess promising antimicrobial activities. Graphical Abstract: [InlineMediaObject not available: see fulltext.]

NEW PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF GRAM-NEGATIVE BACTERIAL INFECTION, CONTAMINATION AND FOULING

New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.

PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF BACTERIAL INFECTIONS

New pyrimidine derivatives of formula (I), optionally with a detectable isotope, pharmaceutical composition and method of preparation thereof. New pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives for use as radiotracer in diagnosing or prognosing bacterial infection in a host mammal.