1074-41-5

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL is used as a synthetic intermediate for the development of certain antibiotics, playing a crucial role in the production of life-saving medications.
Used in Chemical Synthesis:
4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL is utilized as a key intermediate in various chemical synthesis processes, contributing to the creation of a wide range of chemical compounds and products.

InChI:InChI=1/C5H7N3OS/c1-10-5-7-3(6)2-4(9)8-5/h2H,1H3,(H3,6,7,8,9)

Upstream product

• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 1004-40-6 6-amino-2-thioxo-1,2-dihydro-4(3H)-pyrimidinone 
• 1004-40-6 6-Amino-2-thiouracil 
• 74-83-9 methyl bromide 
• 1004-40-6 4-aminothiouracil 
• 65802-56-4 4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate 
• 17356-08-0 thiourea 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 5446-89-9 2-methylsulfanyl-1,7⁽⁹⁾-dihydro-purin-6-one 
• 1005-38-5 4-amino-6-chloro-2-methylthiopyrimidine 
• 104637-63-0 6-amino-2-(morpholin-4'-yl)pyrimidin-4(3H)-one 
• 33080-87-4 6-amino-2-(4'-methylpiperazin-1'-yl)ptrimidin-4(3H)-one 
• 54030-56-7 6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one 
• 43005-49-8 4-amino-5-nitroso-6-oxo-1,2,3,6-tetrahydro-2-methylthiopyrimidine 
• 60722-76-1 4-amino-6-benzyloxy-2-(methylsulfanyl)pyrimidine 
• 140396-41-4 4-amino-1-benzyl-2-(methylsulfanyl)pyrimidin-6(1H)-one 

Relevant academic research and scientific papers

Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents

Abstract: 7-aminopyrimidin-5(1H)-one (5) was utilized as a starting material for the preparation of new, Schiff bases (13–19), amides 23, 24, imide 25, as well as thiourea derivatives 30–33 incorporating the triazolopyrimidines nucleus in their molecules. Structural elucidations for the new compounds were based upon compatible microanalytical and spectroscopic measurement. Biological evaluation indicated that compounds 23, 31, 33, 32, and 30 possess promising antimicrobial activities. Graphical Abstract: [InlineMediaObject not available: see fulltext.]

Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety

7-Amino-3-phenyl-[1,2,4]triazolo [4,3-a] pyrimidin-5(1H)-one (5) was utilized as key intermediate for the synthesis of some new, quinolines 9, 10, 11, 12, 13, 14 and 18, 19, 20, acrylonitrile 25 and 28, coumarin 26, and pyrazoles 31, 32, 33, 34 incorporating triazolopyrimidines. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1H NMR, and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antimicrobial. Compounds 25, 28, 31, 32, 33, and 34 are the most promising.

NEW PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF GRAM-NEGATIVE BACTERIAL INFECTION, CONTAMINATION AND FOULING

New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.

Pyrimidinone derivative, preparation method thereof and application thereof in resisting mycobacterium tuberculosis infection

The invention discloses a pyrimidinone derivative, a preparation method thereof and an application thereof in resisting mycobacterium tuberculosis infection. The structure of the pyrimidinone derivative is shown as a formula I, wherein R1, m, X, Y, Z, R2

PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF BACTERIAL INFECTIONS

New pyrimidine derivatives of formula (I), optionally with a detectable isotope, pharmaceutical composition and method of preparation thereof. New pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives for use as radiotracer in diagnosing or prognosing bacterial infection in a host mammal.

NOVEL N2, N4, N7, 6-TETRASUBSTITUTED PTERIDINE-2,4,7-TRIAMINE AND 2, 4, 6, 7-TETRASUBSTITUTED PTERIDINE COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF

Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing autoimmunity disease using the same are described.

Chemical synthesis of some novel 6-aminouracil-2-thiones and their glycoside analogues

6-AMINOURACIL-2-THIONE (1) and its 5-bromo derivative 2 underwent alkylation yielding their respective S-alkyl products 4a-j. The reaction of compound 1 and aldehydes in the presence of chloroacetic acid afforded the respective thiazolopyrimidinyl acetamides 7a-d. The C-glycosides 8a, b and 9c-e were successfully prepared through condensing compound 1 and the appropriate sugar in the presence of chloroacetic acid. The behavior of certain S-alkyl derivative 4 towards amines and hydrazines was also studied. Structure elucidations for the new products were supported by compatible chemical and spectral measurements.

MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS

Methods of assaying for (i) a pterin by immunoassay employing a pterin as capture agent, (ii) neopterin by chemiluminescent microparticle immunoassay (CMIA) employing an anti-neopterin antibody (Ab) as capture agent, (iii) neopterin by an immunoassay (IA) employing an acridinium (Acr)-labeled anti-neopterin Ab as conjugate, and (iv) neopterin by an IA employing Acr-labeled neopterin as tracer; an Acr-labeled anti-neopterin Ab; a conjugate/complex comprising anti-neopterin Ab and a carrier scaffold; a conjugated pterin; a conjugate comprising an Acr-labeled pterin and a carrier scaffold; an immunogen comprising neopterin and a carrier protein; a conjugate comprising such an immunogen and an Acr compound; an immunogen comprising a carrier protein and a neopterin hapten; a conjugate comprising such an immunogen and an Acr compound; a kit for assaying a pterin comprising a pterin as a capture agent and instructions for IA; and a kit for assaying neopterin comprising an anti-neopterin Ab as a capture agent and instructions for CMIA, neopterin comprising an Acr-labeled anti-neopterin Ab as a conjugate and instructions for IA, or Acr-labeled neopterin as a tracer and instructions for IA.

New approach to synthesize symmetrical and unsymmetrical 6-(N-Alkyl(Aryl)amino)-and 6-(N, N-dialkyl(Aryl)amino)-2,4-bis(Alkyl(Aryl)Thio) pyrimidines as anti-platelet agents

A new and straightforward procedure has been developed for the preparation of symmetrical and unsymmetrical 6-(N-alkyl(aryl)amino)-and 6-(N,N- bisalkyl(aryl)amino)-2,4-bis(alkyl(aryl)thio)pyrimidines. The two identical or different alkylthio groups were s

AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are azolopyridine and azolopyrimidine compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.