1415728-57-2

Basic information

• Product Name: tetr-butyl ((2,4-dichlorophenyl)(phenylsulfonyl)methyl)carbamate
• Synonyms: tetr-butyl ((2,4-dichlorophenyl)(phenylsulfonyl)methyl)carbamate
• CAS NO: 1415728-57-2
• Molecular Weight: 416.325
• Mol File: 1415728-57-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tetr-butyl ((2,4-dichlorophenyl)(phenylsulfonyl)methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tetr-butyl ((2,4-dichlorophenyl)(phenylsulfonyl)methyl)carbamate(1415728-57-2)
• EPA Substance Registry System: tetr-butyl ((2,4-dichlorophenyl)(phenylsulfonyl)methyl)carbamate(1415728-57-2)

Safety Data

• Hazardous Substances Data: 1415728-57-2(Hazardous Substances Data)

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 515-42-4 sodium phenylsulfonate 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 1415114-05-4 (R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-amine 
• 1246770-52-4 ((R)-N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide) 
• 163226-26-4 tert-butyl 2,4-dichlorobenzylidenecarbamate 
• 1415728-55-0 (R)-tert-butyl (1-(2,4-dichlorophenyl)-2-nitroethyl)carbamate 
• 1415728-54-9 (R)-tert-butyl (2-amino-1-(2,4-dichlorophenyl)ethyl)carbamate 
• 1415728-60-7 (R)-tert-butyl (1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)carbamate 

Relevant articles and documents

Organocatalytic, enantioselective synthesis of VNI: A robust therapeutic development platform for Chagas, a neglected tropical disease

VNI is a potent inhibitor of CYP51 and was recently shown to achieve a parasitological cure of mice infected with T. cruzi in both acute and chronic stages of infection. T. cruzi is the causative parasite of Chagas disease, a neglected tropical disease. The first enantioselective chemical synthesis of VNI (at a materials cost of less than $0.10/mg) is described. Furthermore, the key enantioselective step is performed at the 10 g scale.