1415728-60-7

Basic information

• Product Name: (R)-tert-butyl (1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)carbamate
• Synonyms: (R)-tert-butyl (1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)carbamate
• CAS NO: 1415728-60-7
• Molecular Weight: 356.252
• Mol File: 1415728-60-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl (1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl (1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)carbamate(1415728-60-7)
• EPA Substance Registry System: (R)-tert-butyl (1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)carbamate(1415728-60-7)

Safety Data

• Hazardous Substances Data: 1415728-60-7(Hazardous Substances Data)

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 1415728-57-2 tetr-butyl ((2,4-dichlorophenyl)(phenylsulfonyl)methyl)carbamate 
• 163226-26-4 tert-butyl 2,4-dichlorobenzylidenecarbamate 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 1415114-05-4 (R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-amine 

Relevant articles and documents

Organocatalytic, enantioselective synthesis of VNI: A robust therapeutic development platform for Chagas, a neglected tropical disease

VNI is a potent inhibitor of CYP51 and was recently shown to achieve a parasitological cure of mice infected with T. cruzi in both acute and chronic stages of infection. T. cruzi is the causative parasite of Chagas disease, a neglected tropical disease. The first enantioselective chemical synthesis of VNI (at a materials cost of less than $0.10/mg) is described. Furthermore, the key enantioselective step is performed at the 10 g scale.