1415910-80-3Relevant academic research and scientific papers
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors
Biava, Mariangela,Battilocchio, Claudio,Poce, Giovanna,Alfonso, Salvatore,Consalvi, Sara,Di Capua, Angela,Calderone, Vincenzo,Martelli, Alma,Testai, Lara,Sautebin, Lidia,Rossi, Antonietta,Ghelardini, Carla,Di Cesare Mannelli, Lorenzo,Giordani, Antonio,Persiani, Stefano,Colovic, Milena,Dovizio, Melania,Patrignani, Paola,Anzini, Maurizio
, p. 772 - 786 (2014/01/23)
We report herein the development, synthesis, physicochemical and pharmacological characterization of a novel class of pharmacodynamic hybrids that selectively inhibit cyclooxygenase-2 (COX-2) isoform and present suitable nitric oxide releasing properties.
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme
Biava, Mariangela,Battilocchio, Claudio,Poce, Giovanna,Alfonso, Salvatore,Consalvi, Sara,Porretta, Giulio Cesare,Schenone, Silvia,Calderone, Vincenzo,Martelli, Alma,Testai, Lara,Ghelardini, Carla,Di Cesare Mannelli, Lorenzo,Sautebin, Lidia,Rossi, Antonietta,Giordani, Antonio,Patrignani, Paola,Anzini, Maurizio
, p. 287 - 298 (2013/02/23)
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.
