1415919-40-2Relevant academic research and scientific papers
Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide
Zhang, Pei-Zhi,Li, Jian-An,Zhang, Ling,Shoberu, Adedamola,Zou, Jian-Ping,Zhang, Wei
, p. 919 - 923 (2017)
A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.
Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones
Chun, Yu Sung,Kim, Ju Hyun,Choi, Suh Young,Ko, Young Ok,Lee, Sang-Gi
, p. 6358 - 6361 (2013/02/23)
A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presen
