1415982-08-9

Upstream product

• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 1415982-07-8 ethyl 9-(bromozincio)nonanoate 
• 99747-72-5 2,6,6-trimethylcyclohex-1-en-1-yl trifluoromethanesulfonate 
• 28598-81-4 ethyl 9-bromononanoate 

Downstream Products

• 1415982-09-0 9-(2,6,6-trimethylcyclohex-1-en-1-yl)nonanoic acid 

Relevant academic research and scientific papers

COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING SIRNA ACTIVITY

Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of -CH2-, -S-, and -O- or absent; wherein Y is selected from -(CH2)n, -S(CH2)n, -O(CH2)n-, thiophene, -SO2(CH2)n-, and ester, wherein n = 1 -4; wherein a = 1 -4; wherein b=l -4; wherein c=l-4; and wherein Z is a counterion; and compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including one or both of these compounds which are useful for the delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.