1415992-54-9Relevant articles and documents
Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators
Chatzopoulou, Maria,Emer, Enrico,Lecci, Cristina,Rowley, Jessica A.,Casagrande, Anne-Sophie,Moir, Lee,Squire, Sarah E.,Davies, Stephen G.,Harriman, Shawn,Wynne, Graham M.,Wilson, Francis X.,Davies, Kay E.,Russell, Angela J.
supporting information, p. 2421 - 2427 (2020/12/03)
Utrophin modulation is a disease-modifying therapeutic strategy for Duchenne muscular dystrophy that would be applicable to all patient populations. To improve the suboptimal profile of ezutromid, the first-in-class clinical candidate, a second generation