1415995-32-2Relevant academic research and scientific papers
Synthesis and asymmetric hydrogenation of (3E)-1-benzyl-3-[(2-oxopyridin- 1(2H)-yl)methylidene]piperidine-2,6-dione
Bisset, Alexander A.,Shiibashi, Akira,Desmond, Jasmine L.,Dishington, Allan,Jones, Teyrnon,Clarkson, Guy J.,Ikariya, Takao,Wills, Martin
, p. 11978 - 11980 (2013/01/16)
The synthesis of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene] piperidine-2,6-dione 4 from N-benzylglutarimide was achieved in three steps. The asymmetric hydrogenation of 4 gave either the product of partial reduction (10) or full reduction (13), depending on the catalyst which was employed, in high ee in each case. Attempts at asymmetric transfer hydrogenation (ATH) of 4 resulted in formation of a racemic product. The Royal Society of Chemistry.
