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ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

14160-65-7

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14160-65-7 Usage

Synthesis Reference(s)

Tetrahedron Letters, 26, p. 451, 1985 DOI: 10.1016/S0040-4039(00)61908-1

Check Digit Verification of cas no

The CAS Registry Mumber 14160-65-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,6 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14160-65:
(7*1)+(6*4)+(5*1)+(4*6)+(3*0)+(2*6)+(1*5)=77
77 % 10 = 7
So 14160-65-7 is a valid CAS Registry Number.

14160-65-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate

1.2 Other means of identification

Product number -
Other names 2-Ethoxycarbonyl-1,4-cyclohexadione-4-ethylene ketal

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14160-65-7 SDS

14160-65-7Relevant academic research and scientific papers

GLUCOCORTICOID RECEPTOR MODULATORS

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Paragraph 00213, (2020/05/19)

Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.

GLUCOCORTICOID RECEPTOR MODULATORS

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Paragraph 00275, (2018/11/10)

Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.

Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2)

Yang, Michael G.,Xiao, Zili,Shi, Qing,Cherney, Robert J.,Tebben, Andrew J.,De Lucca, George V.,Santella III, Joseph B.,Mo, Ruowei,Cvijic, Mary Ellen,Zhao, Qihong,Barrish, Joel C.,Carter, Percy H.

scheme or table, p. 1384 - 1387 (2012/03/26)

We report the synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamides (4) as CCR2 inhibitors for the potential treatment of inflammatory diseases. Several of the compounds display nanomolar binding affinity for CCR2. The in vitro structure-activity

γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

Cherney, Robert J.,Mo, Ruowei,Meyer, Dayton T.,Voss, Matthew E.,Yang, Michael G.,Santella III, Joseph B.,Duncia, John V.,Lo, Yvonne C.,Yang, Gengjie,Miller, Persymphonie B.,Scherle, Peggy A.,Zhao, Qihong,Mandlekar, Sandhya,Cvijic, Mary Ellen,Barrish, Joel C.,Decicco, Carl P.,Carter, Percy H.

scheme or table, p. 2425 - 2430 (2010/08/05)

We describe the design, synthesis, and evaluation, of γ-lactams as glycinamide replacements within a series of di- and trisubstituted cyclohexane CCR2 antagonists. The lactam-containing trisubstituted cyclohexanes proved to be more potent than the disubst

Cyclic derivatives as modulators of chemokine receptor activity

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Page/Page column 108, (2008/06/13)

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.

Process of preparing N-ureidoalkyl-piperidines

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Page/Page column 4-5, (2008/06/13)

The present application describes a process of preparing a compound of formula (IV), or salt or stereoisomer thereof: wherein Pg, at each occurrence, is independently selected from an amine protecting group; comprising the steps of reacting a compound of Formula with a reducing agent to give a compound of Formula III: reacting the compound of formula (III) with an amine of formula (IIa) using reductive amination to give the compound of formula (III)

Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity

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Page/Page column 32, (2010/02/11)

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.

N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

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Page/Page column 193-194, (2008/06/13)

The present application describes modulators of chemokine receptors of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

N-ureidoalkyl-piperidines as modulators of chemokine receptor activity

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Page 13, (2008/06/13)

The present application describes modulators of chemokine receptor activity of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases, as well as autoimmune pathologies such as rheum

Cyclic derivatives as modulators of chemokine receptor activity

-

, (2008/06/13)

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, restinosis, organ transplantation, and

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