14160-94-2

Basic information

• Product Name: 4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde
• Synonyms: 4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde
• CAS NO: 14160-94-2
• Molecular Formula: C₆H₆ClN₃O
• Molecular Weight: 171.58434
• Mol File: 14160-94-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 152.0-153.7 °C
• Boiling Point: 348.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.442±0.06 g/cm3(Predicted)
• PKA: 1.06±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde(14160-94-2)
• EPA Substance Registry System: 4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde(14160-94-2)

Safety Data

• Hazardous Substances Data: 14160-94-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde, also known as CMAC, is a chemical compound with the molecular formula C6H6ClN3O. It is a heterocyclic aldehyde, a versatile building block in the synthesis of pharmaceutical and agricultural compounds. CMAC is an important intermediate in the production of various chemicals and is used in the pharmaceutical industry for the synthesis of anti-cancer and antiviral drugs. It is also used in the production of agrochemicals and dyes. Additionally, CMAC has potential applications in the field of materials science and the development of organic light-emitting diodes (OLEDs). Due to its diverse range of applications, CMAC is an important chemical compound with significant industrial and commercial value.

Upstream product

• 5305-40-8 2,6-dichloro-pyrimidine carbaldehyde 
• 74-89-5 methylamine 

Relevant articles and documents

Diverse display of non-covalent interacting elements using pyrimidine-embedded polyheterocycles

A series of pyrimidine-embedded polyheterocycles was synthesized using a pDOS strategy in a facile manner. The resulting poly-heterocyclic core skeletons containing a unique aza-tricyclic framework allowed for diverse display of non-covalent interacting e

A cascade reaction with iminium ion isomerization as the key step leading to tetrahydropyrimido[4,5-d]pyrimidines

A novel cascade reaction of aminopyrimidines 1 with N-alkyl amino acids or analogues was investigated. The keys to this cascade are the isomerization of an iminium ion formed between the aldehyde group in pyrimidine and the secondary amine of an amino acid, and subsequent cyclization to the neighboring amino group. This sequence could be useful in the synthesis of novel tetrahydropyrimido[4,5-d]pyrimidine libraries.

SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS

The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.