14160-94-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde is used as an intermediate for the synthesis of anti-cancer and antiviral drugs. Its unique chemical structure allows for the development of new therapeutic agents with potential applications in treating various diseases.
Used in Agrochemical Production:
CMAC is used in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural products. Its role in this industry is crucial for enhancing crop protection and yield.
Used in Dye Manufacturing:
4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde is utilized in the manufacturing of dyes, providing a range of color options for various industries, including textiles, plastics, and printing.
Used in Materials Science:
CMAC has potential applications in the field of materials science, where it can be used to develop new materials with unique properties for various applications.
Used in Organic Light-Emitting Diode (OLED) Development:
4-Chloro-6-(methylamino)pyrimidine-5-carbaldehyde is also used in the development of organic light-emitting diodes (OLEDs), which are increasingly important in the electronics industry for their energy efficiency and potential for flexible displays.

Upstream product

• 5305-40-8 2,6-dichloro-pyrimidine carbaldehyde 
• 74-89-5 methylamine 

Downstream Products

• 1012786-96-7 5-formyl-6-methylamino-4-(phenylthio)pyrimidine 

Relevant academic research and scientific papers

Diverse display of non-covalent interacting elements using pyrimidine-embedded polyheterocycles

A series of pyrimidine-embedded polyheterocycles was synthesized using a pDOS strategy in a facile manner. The resulting poly-heterocyclic core skeletons containing a unique aza-tricyclic framework allowed for diverse display of non-covalent interacting e

Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases

We herein disclose a novel series of 4-aminopyrimidine-5-carbaldehyde oximes that are potent and selective inhibitors of both EGFR and ErbB-2 tyrosine kinases, with IC50 values in the nanomolar range. Structure-activity relationship (SAR) studies elucidated a critical role for the 4-amino and C-6 arylamino moieties. The X-ray co-crystal structure of EGFR with 37 was determined and validated our design rationale.

A cascade reaction with iminium ion isomerization as the key step leading to tetrahydropyrimido[4,5-d]pyrimidines

A novel cascade reaction of aminopyrimidines 1 with N-alkyl amino acids or analogues was investigated. The keys to this cascade are the isomerization of an iminium ion formed between the aldehyde group in pyrimidine and the secondary amine of an amino acid, and subsequent cyclization to the neighboring amino group. This sequence could be useful in the synthesis of novel tetrahydropyrimido[4,5-d]pyrimidine libraries.

SUBSTITUTED PYRIMIDINE KINASE INHIBITORS

The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.

SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS

The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

Synthesis of Thienopyrimidines from 4,6-Dichloropyrimidine-5-carbaldehydes

Several thienopyrimidines have been prepared by intramolecular cyclisation of 6-(substituted methylthio)-5-pyrimidinecarbaldehyde and carbonitrile intermediates derived from 6-chloropyrimidine-5-carbaldehydes and 5-carbonitriles and methyl thioglyc