141602-29-1

Upstream product

• 124703-78-2 6-ethyl-4(3H)-pyrimidinone 
• 141602-28-0 6-ethyl-5-iodo-3H-pyrimidin-4-one 
• 53939-83-6 4-hydroxy-2-mercapto-6-ethylpyrimidine 
• 124703-78-2 6-ethylpyrimidin-4-ol 

Downstream Products

• 1392099-63-6 N-{5-[4-ethyl-6-(6-methyl-pyridin-3-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-2,4-difluoro-benzenesulfonamide 
• 1392099-64-7 N-{5-[4-ethyl-6-(2-methyl-pyridin-4-yl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-2,4-difluoro-benzenesulfonamide 
• 1392099-55-6 N-{5-[4-(3,4-dimethoxy-phenyl)-6-ethyl-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 1392099-56-7 N-{5-[4-(3-dimethylaminomethyl-phenyl)-6-ethyl-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 1392099-61-4 N-{5-[4-ethyl-6-(2-methoxy-3-trifluoromethyl-phenyl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 1392099-62-5 N-{5-[4-ethyl-6-(3-fluoro-4-methoxy-phenyl)-pyrimidin-5-ylethynyl]-2-methyl-pyridin-3-yl}-methanesulfonamide 
• 1391979-24-0 N-[5-(4-chloro-6-ethyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-2,4-difluoro-benzenesulfonamide 
• 1391979-30-8 N-[5-(4-chloro-6-ethyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-4-fluoro-benzenesulfonamide 
• 1391978-22-5 N-{5-[4-(4-cyclopropylpiperazin-1-yl)-6-ethylpyrimidin-5-ylethynyl]-2-methylpyridin-3-yl}-4-fluorobenzenesulfonamide 
• 1391978-21-4 N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide 
• 1391978-20-3 N-[5-(4-ethyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-2-methoxypyridin-3-yl]-benzenesulfonamide 
• 1391978-19-0 N-[5-(4-ethyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamide 

Relevant academic research and scientific papers

5-Alkynyl-pyridines

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification

NEW 5-ALKYNYL-PYRIDINES

5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.

NEW 5-ALKYNYL-PYRIDINES

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

NEW 5-ALKYNYL-PYRIDINES

This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of P13Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

5-ALKYNYL-PYRIMIDINES

The present invention encompasses compounds of general formula (1) wherein R1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

5-ALKYNYL PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS

The present invention encompasses compounds of general formula (1) wherein R1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

5-Iodo-4-phenethylaminopyrimidine derivative, intermediate thereof, processes for producing the same and agricultural and horticultural pesticides

The present invention is to provide a novel 5-iodo-4-phenethylaminopyrimidine derivative represented by the following formula (1): wherein R1represents a halogen atom, a C2-4acyloxy group or a hydroxyl group; R2represents

Aminopyrimidine derivatives as microbicides, insecticides and acaricides

Compounds of formula I STR1 where R1 -R5, R8, R13, m and n are as defined herein. The novel compounds have valuable biocidal properties. They can be used in crop protection for protecting cultivated plants against attack by pests, and for controlling those pests.