141602-36-0

Basic information

• Product Name: 4,5-DICHLORO-6-TRIFLUOROMETHYLPYRIMIDINE
• Synonyms: 4,5-DICHLORO-6-TRIFLUOROMETHYLPYRIMIDINE
• CAS NO: 141602-36-0
• Molecular Formula: C₅HCl₂F₃N₂
• Molecular Weight: 216.98
• Mol File: 141602-36-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 217.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.627±0.06 g/cm3(Predicted)
• PKA: -6.14±0.28(Predicted)
• CAS DataBase Reference: 4,5-DICHLORO-6-TRIFLUOROMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DICHLORO-6-TRIFLUOROMETHYLPYRIMIDINE(141602-36-0)
• EPA Substance Registry System: 4,5-DICHLORO-6-TRIFLUOROMETHYLPYRIMIDINE(141602-36-0)

Safety Data

• Hazardous Substances Data: 141602-36-0(Hazardous Substances Data)

Upstream product

• 1546-78-7 4-trifluoromethyl-1,6-dihydropyrimidine-6-oxide 

Relevant articles and documents

Design, synthesis and antifungal activity of new substituted difluoromethylpyrimidinamine derivatives

Rusts are one of the most important fungal diseases, the known target sites have already developed serious resistance to the main existing classifications of fungicides. In order to discover novel fungicides with a promising activity on rusts, twenty new substituted difluoromethylpyrimidinamine derivatives were designed and synthesized with the aid of the intermediate derivatization methods starting from ethyl 4,4-difluoro-3-oxobutanoate that is the common raw material in some newly launched important succinate dehydrogenase inhibitor (SDHI) fungicides. Their structures were identified by 1H NMR, 13C NMR, 19F NMR, IR, elemental analyses and HRMS. All the compounds were screened for in vivo fungicidal activity against southern corn rust (SCR). The preliminary bioassay results indicated that 5-chloro-6-(difluoromethyl)-N-(2-(6-(3-(trifluoromethyl)phenoxy)pyridin-3-yl)ethyl)pyrimidin-4-amine (compound J, R1 = CHF2, Alk = CH2CH2, Rn = 3-CF3) is the optimal structure with desired fungicidal activity against SCR (EC50 = 2.16 mg/L), significantly higher than commercial fungicides diflumetorim (EC50 = 53.26 mg/L) and propiconazole (EC50 = 3.92 mg/L). The structure–activity relationship of the synthesized compounds was discussed as well. This study also demonstrated that difluoromethylpyrimidinamine derivatives can be further utilized as a promising antifungal agent to control rust. Further synthesis and structure optimization studies are currently in progress.

PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME

The present invention provides a pyrimidine derivative represented by the formula: wherein R1p and R1q are the same or different, and each represents (1)hydrogen, (2)halogen, (3) a C1-6alkyl group which may be substituted or (4) a C1-6alkoxy group, and so on, R2 is halogen, a C1-6alkyl group, cyano group, and so on, Ar is a phenyl group which may be substituted or is a condensed hetero ring which may be substituted, which has excellent selective herbicidal activity, and a herbicide containing the derivative.