1416051-33-6Relevant articles and documents
Stereoselective synthesis of chiral polycyclic indolic architectures through Pd0-catalyzed tandem deprotection/cyclization of tetrahydro-β-carbolines on allenes
Gobé, Valérian,Guinchard, Xavier
, p. 8511 - 8520 (2015)
Enantioenriched N-allyl tetrahydro-β-carbolines were prepared by chiral phosphoric acid-catalyzed Pictet-Spengler reactions. The compounds undergo Pd0-catalyzed cyclizations through a tandem deprotection/cyclization process. The regioselectivit
Domino formation of enamines - Intramolecular cyclizations to 1-aminotetralins from γ-arylallene aldehydes and amines
Gob, Valrian,Retailleau, Pascal,Guinchard, Xavier
, p. 5438 - 5441 (2014)
1,5-/1,6-Allenals conjugated to an aromatic ring undergo a cyclization, in the presence of an amine, that leads to tricyclic compounds including the 1-aminotetralin scaffold. This domino process combines the in situ formation of the enamine and the cyclization affording the tricyclic 1-aminotetralins in very high diastereoselectivities. (Chemical Equation Presented).