14161-09-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Methanesulfonyl-pyrimidine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical properties allow it to be incorporated into the development of new drugs, enhancing their efficacy and therapeutic potential.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Methanesulfonyl-pyrimidine is utilized as a building block for the creation of agrochemicals, such as pesticides and herbicides. Its strong sulfonic acid properties contribute to the effectiveness of these products in controlling pests and weeds.
Used in Dye Industry:
2-Methanesulfonyl-pyrimidine is used as an intermediate in the production of dyes. Its aromatic properties enable the creation of a wide range of colors, making it a valuable component in the dye industry.
Used in Polymer Industry:
In the polymer industry, 2-Methanesulfonyl-pyrimidine is employed as a monomer or a building block in the synthesis of various polymers. Its unique chemical properties contribute to the development of polymers with specific characteristics, such as improved strength, flexibility, or resistance to environmental factors.
Used in Specialty Chemicals Industry:
2-Methanesulfonyl-pyrimidine is used as an intermediate in the production of specialty chemicals, which are tailored to meet specific requirements in various applications. Its versatility and strong chemical properties make it an essential component in the development of these specialized products.

InChI:InChI=1/C5H6N2O2S/c1-10(8,9)5-6-3-2-4-7-5/h2-4H,1H3

Upstream product

• 823-09-6 2-(methylsulfanyl)pyrimidine 
• 7757-82-6 sodium sulfate 

Downstream Products

• 1235447-07-0 C₁₄H₁₅N₃O₂ 
• 503039-42-7 methyl 4-((pyrimidin-2-ylamino)methyl)benzoate 
• 1274750-44-5 C₁₄H₁₅N₃O₂ 
• 332101-38-9 2-[2,3-bis(isopropylthio)benzyl]pyrimidine 
• 93271-75-1 dimethyl pyrimidin-2-ylmalonate 

Relevant academic research and scientific papers

Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y

A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryls following a Homolytic Aromatic Substitution (HAS) pathway. This method has provided a range of α-aminoheteroaryl compounds including a functionalized natural product. The mechanism of this late-stage functionalization of aryls was investigated and suggests the formation of a sulfonyl radical intermediate over a reductive quenching cycle.

Synthesis of Alkylated Pyrimidines via Photoinduced Coupling Using Benzophenone as a Mediator

The synthesis of alkylated pyrimidines was achieved via benzophenone-mediated photoinduced coupling between saturated heterocycles and sulfonylpyrimidines. The pyrimidine ring was selectively introduced at the nonacidic C(sp3)-H bond proximal to heteroatoms including oxygen, nitrogen, and sulfur. This is a coupling reaction mediated solely by photoexcited benzophenone, an organic molecule, without the aid of any metallic catalysts or reagents.

Basic techniques of working on a solid phase: From ABC of the peptide synthesis to libraries of non-natural amino acids

Libraries of hardly available amino acids bearing a heteroaromatic ring (2-pyrimidyl, substituted 2-pyridyl or 2-thiazolyl) at the amino group were prepared using solid-phase synthesis on various resins. The synthesized compounds are structurally similar to some known antidiabetic drugs. The paper combines features of a review (elementary introduction to the solid-phase synthesis methodology and technique for beginners and selected methods from peptide chemistry) and step-by-step experimental protocols (tested by the authors) useful as a methodic tool. The presented protocols (immobilization and modification of amino acids, placing and removal of common protective groups) require no sophisticated equipment and may be useful as pictorial introductory tasks for students education. Pleiades Publishing, Ltd., 2010.

Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto

Compounds having activity as inhibitors of the JNK pathway are disclosed. The compounds of this invention are anilinopyrimidine derivatives having the following structure: wherein R1 through R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to inhibition of the JNK pathway. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto

Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: wherein R1 and R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

Synthesis of 2-isopropylamino-pyrimidine

The present invention provides a process for the synthesis of 2-isopropylamino-pyrimidine by aminolysis of 2-methylsulphonyl-pyrimidine using isopropylamine. The aminolysis is effected, according to the present invention, by refluxing isopropylamine and 2-methylsulphonyl-pyrimidine in the absence of a solvent. Using this technique, the 2-isopropylamino-pyrimidine has been obtained in a substantially quantitative yield.