14161-09-2

Basic information

• Product Name: 2-METHANESULFONYL-PYRIMIDINE
• Synonyms: Methyl pyrimidin-2-yl sulphone;2-METHANESULFONYL-PYRIMIDINE;2-(Methylsulfonyl)pyrimidine
• CAS NO: 14161-09-2
• Molecular Formula: C₅H₆N₂O₂S
• Molecular Weight: 158.18
• Mol File: 14161-09-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 335.647 °C at 760 mmHg
• Flash Point: 156.794 °C
• Appearance: /
• Density: 1.344 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-METHANESULFONYL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHANESULFONYL-PYRIMIDINE(14161-09-2)
• EPA Substance Registry System: 2-METHANESULFONYL-PYRIMIDINE(14161-09-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 14161-09-2(Hazardous Substances Data)

Usage

General Description

2-Methanesulfonyl-pyrimidine is a chemical compound with the molecular formula C5H6N2O2S. It is a pyrimidine derivative that is commonly used in the synthesis of pharmaceuticals and agrochemicals. 2-METHANESULFONYL-PYRIMIDINE is known for its strong aromatic and sulfonic acid properties, making it a valuable building block for the creation of various chemical compounds. It is also used as an intermediate in the production of a wide range of products including dyes, polymers, and specialty chemicals. 2-Methanesulfonyl-pyrimidine is a versatile and important chemical with applications in various industries.

InChI:InChI=1/C5H6N2O2S/c1-10(8,9)5-6-3-2-4-7-5/h2-4H,1H3

Upstream product

• 823-09-6 2-(methylsulfanyl)pyrimidine 
• 7757-82-6 sodium sulfate 

Downstream Products

• 1235447-07-0 C₁₄H₁₅N₃O₂ 
• 1274750-44-5 C₁₄H₁₅N₃O₂ 
• 503039-42-7 methyl 4-((pyrimidin-2-ylamino)methyl)benzoate 
• 332101-38-9 2-[2,3-bis(isopropylthio)benzyl]pyrimidine 
• 93271-75-1 dimethyl pyrimidin-2-ylmalonate 

Relevant articles and documents

Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y

A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryls following a Homolytic Aromatic Substitution (HAS) pathway. This method has provided a range of α-aminoheteroaryl compounds including a functionalized natural product. The mechanism of this late-stage functionalization of aryls was investigated and suggests the formation of a sulfonyl radical intermediate over a reductive quenching cycle.

Basic techniques of working on a solid phase: From ABC of the peptide synthesis to libraries of non-natural amino acids

Libraries of hardly available amino acids bearing a heteroaromatic ring (2-pyrimidyl, substituted 2-pyridyl or 2-thiazolyl) at the amino group were prepared using solid-phase synthesis on various resins. The synthesized compounds are structurally similar to some known antidiabetic drugs. The paper combines features of a review (elementary introduction to the solid-phase synthesis methodology and technique for beginners and selected methods from peptide chemistry) and step-by-step experimental protocols (tested by the authors) useful as a methodic tool. The presented protocols (immobilization and modification of amino acids, placing and removal of common protective groups) require no sophisticated equipment and may be useful as pictorial introductory tasks for students education. Pleiades Publishing, Ltd., 2010.

Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto

Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: wherein R1 and R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.