14161-67-2Relevant academic research and scientific papers
Aluminum Chloride Promoted Cross-Coupling of Trisubstituted Enol Phosphates with Organozinc Reagents En Route to the Stereoselective Synthesis of Tamoxifen and Its Analogues
Kotek, Vladislav,Polák, Peter,Dvo?áková, Hana,Tobrman, Tomá?
supporting information, p. 5037 - 5044 (2016/10/26)
A new method for the stereoselective cross-coupling reaction of arylzinc chlorides with trisubstituted enol phosphates is described. The developed method requires aluminum chloride as a promoter, and the reaction conditions tolerate various functional groups. The observed reactivity pattern of trisubstituted enol phosphates was used for the stereoselective preparation of tamoxifen and its analogues.
Efficient synthesis of polysubstituted olefins using stable palladium nanocatalyst: Applications in synthesis of tamoxifen and isocombretastatin A4
Ganapathy, Dhandapani,Sekar, Govindasamy
supporting information, p. 3856 - 3859 (2014/08/18)
A phosphine-free stable palladium nanocatalyst was used for an efficient synthesis of polysubstituted olefins from N-tosylhydrazones and aryl iodides. This methodology was successfully utilized in the synthesis of biologically important tamoxifen and isocombretastatin A4. The nanocatalyst was easily recovered and reused without any apparent loss in size and catalytic activity.
Synthesis of dienes by palladium-catalyzed couplings of tosylhydrazones with aryl and alkenyl halides
Barluenga, Jose,Tomas-Gamasa, Maria,Aznar, Fernando,Valdes, Carlos
scheme or table, p. 3235 - 3240 (2011/02/28)
Two different combinations of coupling partners can be employed for the synthesis of conjugated dienes by palladium-catalyzed cross-coupling with tosylhydrazones: α,β-unsaturated ketone and aryl halide or alkenyl halide and non-conjugated tosylhydrazone. Depending on the substrate, a vinylogous hydride elimination is responsible for the formation of the final dienes. Copyright
Microwave-assisted, Pd(0)-catalyzed cross-coupling of diazirines with aryl halides
Zhao, Xia,Wu, Guojiao,Yan, Chong,Lu, Kui,Li, Hui,Zhang, Yan,Wang, Jianbo
supporting information; experimental part, p. 5580 - 5583 (2011/02/23)
Pd(0)-catalyzed cross-coupling reactions of diazirines with aryl halides under microwave heating conditions afford a series of substituted olefins. A reaction mechanism involving the migratory insertion of the Pd carbene intermediate is proposed.
