1416172-11-6

Basic information

• Product Name: 5-(1-(2,3-dimethylphenyl)ethyl)-4-tosyl-4,5-dihydrooxazole
• Synonyms: 5-(1-(2,3-dimethylphenyl)ethyl)-4-tosyl-4,5-dihydrooxazole
• CAS NO: 1416172-11-6
• Molecular Weight: 357.474
• Mol File: 1416172-11-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(1-(2,3-dimethylphenyl)ethyl)-4-tosyl-4,5-dihydrooxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-(2,3-dimethylphenyl)ethyl)-4-tosyl-4,5-dihydrooxazole(1416172-11-6)
• EPA Substance Registry System: 5-(1-(2,3-dimethylphenyl)ethyl)-4-tosyl-4,5-dihydrooxazole(1416172-11-6)

Safety Data

• Hazardous Substances Data: 1416172-11-6(Hazardous Substances Data)

Upstream product

• 42432-45-1 2-(2,3-dimethylphenyl)-2-methyloxirane 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 576-23-8 2,3-dimethylbromobenzene 

Downstream Products

• 86347-14-0 medetomidine 

Relevant articles and documents

Preparation method of medetomidine and intermediate thereof

The invention relates to a preparation method of 2-(2, 3-xylyl)-2-methyloxirane. The method is characterized in that the preparation process includes the following reaction shown as the specification, wherein Y is selected from Cl, Br, I, CH3SO4 or HSO4; alkali is selected from KOH, NaOH, LiOH, CsOH, K2CO3, Li2CO3, Cs2CO3, Na2CO3, EtONa, EtOK, (CH3)2CHONa, (CH3)2CHOK, (CH3)3CONa, (CH3)3COK, NH2Na or NH2K. The invention adopts the synthesis method using the 2-(2, 3-xylyl)-2-methyloxirane critical intermediate to prepare medetomidine.

METHOD FOR THE PREPARATION OF MEDETOMIDINE WITH CHLOROACETONE

The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and chloroacetone.