42432-45-1

Basic information

• Product Name: 2-(2,3-dimethylphenyl)-2-methyloxirane
• Synonyms: 2-(2,3-dimethylphenyl)-2-methyloxirane
• CAS NO: 42432-45-1
• Molecular Weight: 162.232
• Mol File: 42432-45-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(2,3-dimethylphenyl)-2-methyloxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,3-dimethylphenyl)-2-methyloxirane(42432-45-1)
• EPA Substance Registry System: 2-(2,3-dimethylphenyl)-2-methyloxirane(42432-45-1)

Safety Data

• Hazardous Substances Data: 42432-45-1(Hazardous Substances Data)

Upstream product

• 2142-71-4 1-(2,3-dimethyl-phenyl)-ethanone 
• 91130-37-9 1-isopropenyl-2,3-dimethyl-benzene 
• 156744-78-4 (2-(2,3-xylyl)-2-propanol) 
• 576-23-8 2,3-dimethylbromobenzene 
• 78-95-5 chloroacetone 

Downstream Products

• 1416172-11-6 5-(1-(2,3-dimethylphenyl)ethyl)-4-tosyl-4,5-dihydrooxazole 
• 86347-14-0 medetomidine 

Relevant articles and documents

Preparation method of medetomidine and intermediate thereof

The invention relates to a preparation method of 2-(2, 3-xylyl)-2-methyloxirane. The method is characterized in that the preparation process includes the following reaction shown as the specification, wherein Y is selected from Cl, Br, I, CH3SO4 or HSO4; alkali is selected from KOH, NaOH, LiOH, CsOH, K2CO3, Li2CO3, Cs2CO3, Na2CO3, EtONa, EtOK, (CH3)2CHONa, (CH3)2CHOK, (CH3)3CONa, (CH3)3COK, NH2Na or NH2K. The invention adopts the synthesis method using the 2-(2, 3-xylyl)-2-methyloxirane critical intermediate to prepare medetomidine.

METHOD FOR THE PREPARATION OF MEDETOMIDINE

The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and aceton.

METHOD FOR THE PREPARATION OF 2-(2,3-DIMETHYLPHENYL)-1-PROPANAL

The invention discloses a method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal starting from 1-bromo 2,3-dimethylbenzene and chloroacetone, its use in perfumes and its use for the preparation of medetomidine.