1416404-30-2

Upstream product

• 1395687-93-0 C₂₂H₂₉NO₃ 
• 1416404-25-5 (1S,5S,6R)-2-allyl-6-(tert-butyldimethylsilyloxy)-1-vinyl-2-azaspiro{bicyclo[3.3.1]nonane-4,2′-[1,3]dioxolane} 
• 1395687-85-0 (1S,5S,6R)-2-allyl-1-vinyl-2-azaspiro[bicyclo[3.3.1]nonane-4,2′-[1,3]dioxolan]-6-ol 
• 1254985-48-2 (R)-1-allyl-3-benzyloxy-2,6-piperidinedione 
• 1395687-78-1 C₁₅H₂₃NO₃ 
• 1395687-70-3 (3R,6R)-6-[2-(1,3-dioxolan-2-yl)ethyl]-1-allyl-6-vinylpiperidin-3-ol 
• 1395687-62-3 (2R,5R)-2-[2-(1,3-dioxolan-2-yl)ethyl]-1-allyl-5-(benzyloxy)-2-vinylpiperidine 
• 1395687-54-3 (R)-1-allyl-5-(benzyloxy)piperidin-2-one 

Downstream Products

• 1395688-09-1 C₂₀H₂₃NO₄ 
• 1395688-17-1 C₁₈H₁₉NO₃ 
• 1395688-24-0 C₂₆H₂₇NO₄ 
• 1395688-32-0 C₂₆H₂₉NO₄ 
• 1395688-41-1 C₂₆H₃₁NO₄ 
• 1395688-49-9 C₃₂H₄₅NO₄Si 
• 1395688-56-8 C₃₂H₄₄N₄O₄Si 
• 1395688-79-5 C₃₂H₄₄N₄O₄Si 
• 1395688-64-8 C₃₀H₄₈N₂O₆Si 
• 361519-96-2 (2S,5S,6S,7S,8R,10aS)-octahydro-5-[(4-methoxyphenyl)methyl]-2-methylamino-1H-7,10a-methanopyrrolo[1,2-a]azocine-6,8-diol 
• 361519-97-3 Phosphoric acid dibenzyl ester (1S,3S,6S,7S,8R,9S)-7-hydroxy-6-(4-methoxy-benzyl)-3-methylamino-5-aza-tricyclo[6.3.1.0^1,5]dodec-9-yl ester 
• 248948-75-6 (2S,5S,6S,7R,8S,10aS)-2-[[(benzyloxy)carbonyl]methylamino]octahydro-6-hydroxy-5-[(4-methoxyphenyl)methyl]-1H-7,10a-methanopyrrolo[1,2-a]azocin-8-yl dibenzyl phosphate 
• 1416404-33-5 C₂₀H₃₁N₂O₆P*ClH 
• 1395688-01-3 C₂₂H₂₇NO₄ 

Relevant academic research and scientific papers

Enantioselective total syntheses of (-)-FR901483 and (+)-8- epi -FR901483

The enantioselective total syntheses of the potent immunosuppressant FR901483 (1) and its 8-epimer (47) have been accomplished. Our approach features the use of building block 6 as the chiron, the application of the one-pot amide reductive bis-alkylation method to construct the chiral aza-quaternary center (dr = 9:1), regio- and diastereoselective intramolecular aldol reaction to build the bridged ring, and RCM to form the 3-pyrrolin-2-one ring.