1416420-00-2

Upstream product

• 1897-45-6 chlorothalonil 
• 41727-48-4 methyl 4-amino-3,5-dichlorobenzoate 
• 1416422-30-4 3,5-dichloro-4-(2,3,5-trichloro-4,6-dicyanophenylamino)benzoyl chloride 
• 106-47-8 4-chloro-aniline 
• 1416419-98-1 C₁₆H₆Cl₅N₃O₂ 
• 1416420-02-4 C₁₅H₄Cl₅N₃O₂ 

Relevant academic research and scientific papers

USE OF SUBSTITUTED DIPHENYLAMINE COMPOUNDS IN PREPARING ANTI-TUMOUR DRUGS

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) showed po

SUBSTITUTE DIPHENYLAMINE COMPOUNDS USE THEREOF AS ANTITUMOR AGENTS

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

SUBSTITUTED CYANOANILINE COMPOUNDS, PREPARATION AND USE THEREOF

Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agriculture and effectively

SUBSTITUTED CYANOANILINE COMPOUNDS, PREPARATION AND USE THEREOF

Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agriculture and effectively

Design, synthesis, and structure-activity relationship of novel aniline derivatives of chlorothalonil

Chlorothalonil with both low cost and low toxicity is a popularly used fungicide in the agrochemical field. The presence of nucleophilic groups on this compound allows further chemical modifications to obtain novel chlorothalonil derivatives. Fluazinam, another commercially available agent with a broad fungicidal spectrum, has a scaffold of diaryl amine structure. To mimic this backbone structure, a variety of (un)substituted phenyl amines was used as nucleophilic agents to react with chlorothalonil to obtain compounds with a diphenyl amine structure. Via an elegant design, two leads, 2,4,5-trichloro-6- (2,4-dichlorophenylamino)isophthalonitrile (7) and 2,4,5-trichloro-6-(2,4,6- trichlorophenylamino)isophthalonitrile (11), with potential fungicidal activity were discovered after a preliminary bioassay screen. These two leads were further modified to obtain final products by replacing the chlorine groups in the phenyl ring in phenyl amine with other functional groups. These functional groups with various electronic properties and spatial characteristics were considered to explore the relationship between structure and fungicidal activity. The results indicate that the electron-withdrawing group NO 2 on the 4 position on the right phenyl ring plays a unique role on enhancing the fungicidal activity. The compounds were identified by proton nuclear magnetic resonance and elemental analysis. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against cucumber downy mildew at 25 mg/L. Compound 20 has been shown as the optimal structure with 85% control against cucumber downy mildew at 6.25 mg/L concentration. The relationship between structure and fungicidal activity is reported. The present work demonstrates that chlorothalonil derivatives can be used as possible lead compounds for developing novel fungicides.