1416422-39-3

Basic information

• Product Name: (6-benzyloxy-7-fluoro-2-methyl-chroman-2-yl)methanol
• Synonyms: (6-benzyloxy-7-fluoro-2-methyl-chroman-2-yl)methanol
• CAS NO: 1416422-39-3
• Molecular Weight: 302.345
• Mol File: 1416422-39-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6-benzyloxy-7-fluoro-2-methyl-chroman-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (6-benzyloxy-7-fluoro-2-methyl-chroman-2-yl)methanol(1416422-39-3)
• EPA Substance Registry System: (6-benzyloxy-7-fluoro-2-methyl-chroman-2-yl)methanol(1416422-39-3)

Safety Data

• Hazardous Substances Data: 1416422-39-3(Hazardous Substances Data)

Upstream product

• 1416422-38-2 C₁₉H₁₉FO₄ 
• 55660-73-6 2-fluoro-1,4-hydroquinone 
• 367-12-4 2-fluorophenol 

Downstream Products

• 1416422-40-6 6-benzyloxy-7-fluoro-2-methyl-chroman-2-carbaldehyde 
• 1416422-53-1 C₃₃H₄₉FO₃ 

Relevant articles and documents

Synthesis and screening of novel vitamin e derivatives for anticancer functions

α-TEA, RRR-α-tocopherol ether linked acetic acid, exhibits potent anticancer actions in vitro and in vivo; whereas, the parent molecule has no anticancer activity. In this study, we incorporated fluorine at the chroman head and/or ether linkage between the chroman head and phytyl tail of α-TEA as well as RRR-α-tocopherol to synthesize 6 vitamin E derivatives, and evaluated the anticancer actions in vitro for ability to induce cell death by apoptosis of human MCF-7 and MDA-MB-231 breast cancer cell lines and mouse mammary cancer cell line 66cl-4GFP. All derivatives, with the exception of compound 12, exhibited anticancer properties. The modified α-TEA ether-type phytyl group exhibited the highest pro-apoptotic activity in comparison with α-TEA as well as other vitamin E derivatives.