1416438-86-2Relevant academic research and scientific papers
An expedient synthesis of 2,4,6-tris(trifluoromethyl)aniline
Edelbach, Brian L.,Pharoah, Blaze M.,Bellows, Sarina M.,Thayer, Peter R.,Fennie, Charles N.,Cowley, Ryan E.,Holland, Patrick L.
, p. 3595 - 3597 (2012)
A simple two-step synthetic route leads to 2,4,6-tris(trifluoromethyl) aniline. It proceeds through deprotonation and iodination of 1,3,5-tris(trifluoromethyl)benzene, followed by copper-catalyzed amination. Georg Thieme Verlag KG Stuttgart - New York.
Catalyst-controlled aliphatic C—H oxidations
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Page/Page column 30; 82-83; 85, (2018/04/20)
The invention provides simple small molecule, non-heme iron catalyst systems with broad substrate scope that can predictably enhance or overturn a substrate's inherent reactivity preference for sp3-hybridized C—H bond oxidation. The invention also provides methods for selective aliphatic C—H bond oxidation. Furthermore, a structure-based catalyst reactivity model is disclosed that quantitatively correlates the innate physical properties of the substrate to the site-selectivities observed as a function of the catalyst. The catalyst systems can be used in combination with oxidants such as hydrogen peroxide to effect highly selective oxidations of unactivated sp3 C—H bonds over a broad range of substrates.
