1-iodo-2,4,6-tris(trifluoromethyl)benzene

Base Information

• Chemical Name: 1-iodo-2,4,6-tris(trifluoromethyl)benzene
• CAS No.: 1416438-86-2
• Molecular Formula: C₉H₂F₉I
• Molecular Weight: 408.005
• Mol file: 1416438-86-2.mol

Synonyms:1-iodo-2,4,6-tris(trifluoromethyl)benzene

Chemical Property of 1-iodo-2,4,6-tris(trifluoromethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-iodo-2,4,6-tris(trifluoromethyl)benzene

There total 1 articles about 1-iodo-2,4,6-tris(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,3,5-tris(trifluoromethyl)benzene (729-81-7) → 1-iodo-2,4,6-tris(trifluoromethyl)benzene (1416438-86-2)

Guidance literature:

1,3,5-tris(trifluoromethyl)benzene; With lithium diisopropyl amide; In diethyl ether; at 0 ℃; for 1.25h; Inert atmosphere;

With iodine; In diethyl ether; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1055/s-0032-1316809

Reference yield: 84.0%

2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1351378-73-8) + 1-iodo-2,4,6-tris(trifluoromethyl)benzene (1416438-86-2) → 2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(2,4,6-tris(trifluoromethyl)phenyl)pyridine

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; toluene; at 100 ℃; for 24h; Inert atmosphere;

Reference yield: 55.0%

1-iodo-2,4,6-tris(trifluoromethyl)benzene (1416438-86-2) → 2,4,6-tris(trifluoromethyl)aniline (25753-22-4)

Guidance literature:

With copper(I) oxide; sodium azide; In dimethyl sulfoxide; at 80 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0032-1316809

upstream raw materials:

1,3,5-tris(trifluoromethyl)benzene

Downstream raw materials:

2,4,6-tris(trifluoromethyl)aniline