1416560-86-5

Basic information

• Product Name: C₁₈H₁₈BrNO₄S
• Synonyms: C₁₈H₁₈BrNO₄S
• CAS NO: 1416560-86-5
• Molecular Weight: 424.315
• Mol File: 1416560-86-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₈BrNO₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₈BrNO₄S(1416560-86-5)
• EPA Substance Registry System: C₁₈H₁₈BrNO₄S(1416560-86-5)

Safety Data

• Hazardous Substances Data: 1416560-86-5(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 1001756-23-5 methyl 7-bromo-3-quinolinecarboxylate 

Relevant articles and documents

Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside

In methods employing molecular probes to explore the targets of bioactive small molecules, long or rigid linker moieties are thought to be critical factors for efficient tagging of target protein. We previously reported the synthesis of a jasmonate glucoside probe with a highly rigid linker consisting of a triazoyl-phenyl (TAzP) moiety, and this probe demonstrated effective target tagging. Here we compare the TAzP probe with other rigid or flexible probes with respect to target tagging efficiency, hydrophobic parameters, aqueous solubility, and dihedral angles around the biaryl linkage by a combination of empirical and calculation methods. The rigid biaryl linkage of the TAzP probe has a skewed conformation that influences its aqueous solubility. Such features that include rigidness and good aqueous solubility resulted in highly efficient target tagging. These findings provide a promising guideline toward designing of better linkers for improving molecular probe performance.