1416737-47-7

Basic information

• Product Name: C₁₂H₁₅BrClNO₃
• Synonyms: C₁₂H₁₅BrClNO₃
• CAS NO: 1416737-47-7
• Molecular Weight: 336.613
• Mol File: 1416737-47-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₅BrClNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₅BrClNO₃(1416737-47-7)
• EPA Substance Registry System: C₁₂H₁₅BrClNO₃(1416737-47-7)

Safety Data

• Hazardous Substances Data: 1416737-47-7(Hazardous Substances Data)

Upstream product

• 6191-99-7 (2E)-3-ethoxyprop-2-enoyl chloride 
• 863127-76-8 (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide 

Downstream Products

• 1323138-80-2 N-(2-chloro-6-methylphenyl)-2-(2-chloroacetamido)-5-thiazolecarboxamide 
• 1323138-54-0 N-(2-chloro-6-methylphenyl)-2-[2-(pyrrolidin-1-yl)acetamido]-5-thiazolecarboxamide 
• 1323138-55-1 N-(2-chloro-6-methylphenyl)-2-[2-(piperidin-1-yl)acetamido]-5-thiazolecarboxamide 
• 1323138-58-4 N-(2-chloro-6-methylphenyl)-2-[2-(morpholin-4-yl)acetamido]-5-thiazolecarboxamide 
• 1323138-60-8 N-(2-chloro-6-methylphenyl)-2-[2-(4-methyl-1-piperazinyl)acetamido]-5-thiazolecarboxamide 
• 1323138-62-0 N-(2-chloro-6-methylphenyl)-2-[2-(4-(2-hydroxyethyl)-1-piperazinyl)acetamido]-5-thiazolecarboxamide 
• 1323138-63-1 2-(2-(azepan-1-yl)acetamido)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 
• 302964-24-5 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide 

Relevant articles and documents

Synthesis and biological activities of 2-amino-thiazole-5-carboxylic acid phenylamide derivatives

In an attempt to develop potent and selective anti-tumor drugs, a series of novel 2-amino-thiazole-5-carboxylic acid phenylamide derivatives were designed based on the structure of dasatinib. All compounds were synthesized by a systematic combinatorial chemical approach. Biological evaluation revealed that N-(2-chloro-6-methylphenyl)-2-(2-(4-methylpiperazin-1-yl)acetamido) thiazole-5-carboxamide (6d) exhibited high antiproliferative potency on human K563 leukemia cells comparable to dasatinib. Against mammary and colon carcinoma cells 6d was either inactive (MDA-MB 231) or distinctly less active (MCF-7 and HT-29: IC50=20.2 and 21.6μM, respectively). Dasatinib showed at each cell line IC501μM. The results of this structure activity relationship study clearly documented that the pyrimidin-4-ylamino core of dasatinib is responsible for the anti-tumor activity against non-leukemia cell lines.