1416767-40-2Relevant academic research and scientific papers
Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: The total synthesis (±)-cavidine Dedicated to the memory of Sandy McKillop - Colleague, mentor, collaborator and friend
Kitsiou, Christiana,Unsworth, William P.,Coulthard, Graeme,Taylor, Richard J.K.
, p. 7172 - 7180 (2015/06/23)
The direct imine acylation (DIA) and subsequent cyclisation of a range of imines with ortho-substituted benzoic acid derivatives is described. Variation in the coupling reagents, imine and benzoic acid were all examined. The DIA procedure was also applied in the total synthesis of (±)-cavidine.
Direct imine acylation: Rapid access to diverse heterocyclic scaffolds
Unsworth, William P.,Kitsiou, Christiana,Taylor, Richard J. K.
, p. 258 - 261 (2013/03/13)
A simple and efficient procedure to prepare a range of diverse heterocycles by the direct acylation of imines using a variety of functionalized benzoic acids is described. The methodology features a novel method for N-acyliminium ion generation followed by in situ intramolecular trapping by oxygen-, nitrogen-, sulfur-and carbon-based nucleophiles. Preliminary mechanistic studies, using ReactIR, are also reported.
