1416767-50-4

Basic information

• Product Name: 3,3-dibenzyl-4-methyl-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazolin-9(1H)-one
• Synonyms: 3,3-dibenzyl-4-methyl-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazolin-9(1H)-one
• CAS NO: 1416767-50-4
• Molecular Weight: 382.505
• Mol File: 1416767-50-4.mol

Chemical Properties

• CAS DataBase Reference: 3,3-dibenzyl-4-methyl-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazolin-9(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-dibenzyl-4-methyl-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazolin-9(1H)-one(1416767-50-4)
• EPA Substance Registry System: 3,3-dibenzyl-4-methyl-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazolin-9(1H)-one(1416767-50-4)

Safety Data

• Hazardous Substances Data: 1416767-50-4(Hazardous Substances Data)

Upstream product

• 119-68-6 N-Methylanthranilic acid 
• 1416767-54-8 4,4-dibenzyl-3,4-dihydro-2H-pyrrole 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: The total synthesis (±)-cavidine Dedicated to the memory of Sandy McKillop - Colleague, mentor, collaborator and friend

The direct imine acylation (DIA) and subsequent cyclisation of a range of imines with ortho-substituted benzoic acid derivatives is described. Variation in the coupling reagents, imine and benzoic acid were all examined. The DIA procedure was also applied in the total synthesis of (±)-cavidine.

Direct imine acylation: Rapid access to diverse heterocyclic scaffolds

A simple and efficient procedure to prepare a range of diverse heterocycles by the direct acylation of imines using a variety of functionalized benzoic acids is described. The methodology features a novel method for N-acyliminium ion generation followed by in situ intramolecular trapping by oxygen-, nitrogen-, sulfur-and carbon-based nucleophiles. Preliminary mechanistic studies, using ReactIR, are also reported.