1416775-85-3

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 89598-96-9 (3-bromophenyl)boronic acid 
• 1059536-36-5 1-(3-bromophenyl)piperidine-4-carboxylic acid 
• 64-17-5 ethanol 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 1059536-36-5 1-(3-bromophenyl)piperidine-4-carboxylic acid 
• 1416775-86-4 1-(3-bromophenyl)-N,N-dimethylpiperidine-4-carboxamide 
• 1416775-87-5 N,N-dimethyl-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-4-carboxamide 
• 1416775-89-7 tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[4-(dimethylcarbamoyl)piperidin-1-yl]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate 
• 1416775-88-6 tert-butyl (1-{4-[(6-{3-[4-(dimethylcarbamoyl)piperidin-1-yl]phenyl}-3-nitropyridin-2-yl)amino]phenyl}cyclobutyl)carbamate 
• 1580440-29-4 1-(4'-fluoro-[1,1'-biphenyl]-3-yl)piperidine-4-carboxylic acid 
• 1580436-89-0 1-(4'-fluoro-[1,1'-biphenyl]-3-yl)-N-(3-methylquinuclidin-3-yl)piperidine-4-carboxamide 
• 1580440-28-3 ethyl 1-(4'-fluoro-[1,1'-biphenyl]-3-yl)piperidine-4-carboxylate 
• 1580440-30-7 1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-4-carboxylic acid ethyl ester 
• 1416775-68-2 1-(3-bromophenyl)-N-isopropylpiperidine-4-carboxamide 

Relevant academic research and scientific papers

AROMATIC SIX-MEMBERED RING DERIVATIVE HAVING SUBSTITUENT AT META POSITION

PROBLEM TO BE SOLVED: To provide a compound having excellent inhibitory activity against a retinoic acid receptor-related orphan receptor γt. SOLUTION: Provided is a compound represented by a formula (I) or a pharmacologically acceptable salt thereof. [R1 is a C3 to C6 cycloalkyl group or a phenyl group which may be substituted with 1 to 4 substituents selected from a substituent group A; R2 is H, a C2 to C7 carboxyalkyl group, OH, or the like; a formula -U-T- represents a formula -CH2-CH2- or a formula -CH=CH-; R3 and R4 each independently represents H, a halogen, or a C1 to C6 alkyl group; Y represents a methylene group or O; R5 represents a phenyl group, a pyridyl group, or the like which may be substituted with 1 to 4 substituents selected from a substituent group B; Q1 is N or a formula =C(R6)-; Q2 is N or a formula =C(R7)-; R6 and R7 are each independently H, a halogen, or the like; the substituent group A includes C1 to C6 alkyl sulfonyl groups or the like; and the substituent group B includes a halogen, C1 to C6 alkyl groups, a hydroxyl group, or the like.] SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Substituted Imidazopyridinyl-Aminopyridine Compounds

The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.