1416904-94-3

Basic information

• Product Name: (-)-diethyl (1-acetamido-2-phenylethyl)phosphonate
• Synonyms: (-)-diethyl (1-acetamido-2-phenylethyl)phosphonate
• CAS NO: 1416904-94-3
• Molecular Weight: 299.307
• Mol File: 1416904-94-3.mol

Chemical Properties

• CAS DataBase Reference: (-)-diethyl (1-acetamido-2-phenylethyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-diethyl (1-acetamido-2-phenylethyl)phosphonate(1416904-94-3)
• EPA Substance Registry System: (-)-diethyl (1-acetamido-2-phenylethyl)phosphonate(1416904-94-3)

Safety Data

• Hazardous Substances Data: 1416904-94-3(Hazardous Substances Data)

Upstream product

• 919-19-7 diethyl acetylphosphonate 
• 78980-61-7 diethyl [1-(acetylamino)ethen-1-yl]phosphonate 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)

Thienopyrimidine-based allosteric inhibitors of the human farnesyl pyrophosphate synthase (hFPPS), characterized by a chiral α-aminophosphonic acid moiety, were synthesized as enantiomerically enriched pairs, and their binding mode was investigated by X-ray crystallography. A general consensus in the binding orientation of all (R)- and (S)-enantiomers was revealed. This finding is a prerequisite for establishing a reliable structure-activity relationship (SAR) model.

Chiral α-amino phosphonates via rhodium-catalyzed asymmetric 1,4-addition reactions

A new approach for the preparation of enantioenriched α-amino phosphonates and derivatives is described. Indeed, the rhodium-catalyzed asymmetric 1,4-addition of potassium organotrifluoroborates to dehydroaminophosphonates afforded α-amino phosphonates in