1416959-00-6Relevant articles and documents
Expanding insight into asymmetric palladium-catalyzed allylic alkylation of N-heterocyclic molecules and cyclic ketones
Bennett, Nathan B.,Duquette, Douglas C.,Kim, Jimin,Liu, Wen-Bo,Marziale, Alexander N.,Behenna, Douglas C.,Virgil, Scott C.,Stoltz, Brian M.
supporting information, p. 4414 - 4418 (2013/04/23)
Eeny, meeny, miny.?? enaminones! Lactams and imides have been shown to consistently provide enantioselectivities substantially higher than other substrate classes previously investigated in the palladium-catalyzed asymmetric decarboxylative allylic alkylation. Several new substrates have been designed to probe the contributions of electronic, steric, and stereoelectronic factors that distinguish the lactam/imide series as superior alkylation substrates (see scheme). These studies culminated in marked improvements on carbocyclic allylic alkylation substrates. Copyright
