1416970-97-2Relevant academic research and scientific papers
Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: A generalization of the Hantzsch pyrrole synthesis
Estevez, Veronica,Villacampa, Mercedes,Menendez, J. Carlos
, p. 591 - 593 (2013)
A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(iv) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone preparation with a general version of the classical Hantzsch pyrrole synthesis.
