1416975-30-8Relevant articles and documents
ADDICTION TREATMENT OF AN ALCOHOL-CONSUMING PATIENT POPULATION
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, (2020/05/19)
Disclosed herein are methods of treating addiction to a dopamine-producing agent (e.g., amphetamine, cocaine, nicotine, opioids) in patient populations that do not exclude alcohol consumption during treatment. The methods generally comprise administering to the patient a therapeutically effective amount of an aldehyde dehydrogenase-2 (ALDH-2) inhibitor, such as compound (1).
COMBINATION THERAPY FOR PREVENTING ADDICTION
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, (2019/05/10)
Disclosed is a novel combination therapy to reduce or prevent the acquisition of a conditioned response in a mammal comprising administering to the mammal a therapeutically effective amount of an aldehyde dehydrogenase (ALDH-2) inhibitor compound, such as a compound of Formula (I), in combination with a substance that produces the conditioned response, such as a medication containing a dopamine-producing agent such as an opioid, whereby the combination acts to reduce or prevent the acquisition of a conditioned response, and the deleterious side-effect of misuse, dependence, abuse, and/or addiction.