1416982-60-9Relevant articles and documents
Method of preparing SYP-14288
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Paragraph 0010; 0041; 0044; 0045, (2017/09/23)
The invention belongs to the field of organic synthesis and particularly relates to a preparation method of SYP-14288. The method includes the steps of: adding a reaction solvent A to 2,6-dichloro-3,5-dinitrotoluene, adding dropwisely ammonia water or feeding ammonia gas to the solution at from 0 DEG C to reflux temperature of the solvent A, continuously performing the reaction for 1-10 h, and removing the solvent after the reaction is finished to obtain an intermediate substituted ammoniated substance; performing a reaction to the substituted ammoniated substance, 3,5-dichloro-4-fluoronitrobenzene, an alkali and a reaction solvent B for 1-20 h at from room temperature to reflux condition of the solvent B; and removing the solvent after the reaction is finished, performing post-treatment to obtain a crude product, and re-crystallizing the crude product to obtain the product, SYP-14288. The product SYP-14288 is high in purity and yield. The method employs easy-to-obtained raw materials, has simple operations and mild reaction conditions, and is suitable for industrial production.
INTEGRATED PROCESS FOR THE PREPARATION OF POLYBENZIMIDAZOLE PRECURSORS
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Page/Page column 6, (2010/07/04)
An integrated process is provided for preparing complexes of 2,3,5,6-tetraminotoluene with an aromatic diacid starting with nitration of 2,6-dihalotoluene. The process design eliminates costly intermediate drying and recrystallization steps. Handling of s
