1416986-64-5

Basic information

• Product Name: C₃₃H₃₄O₄
• CAS NO: 1416986-64-5
• Molecular Weight: 494.631
• Mol File: 1416986-64-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₃₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₃₄O₄(1416986-64-5)
• EPA Substance Registry System: C₃₃H₃₄O₄(1416986-64-5)

Safety Data

• Hazardous Substances Data: 1416986-64-5(Hazardous Substances Data)

Upstream product

• 191480-69-0 (3R,4S)-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopent-1-ene 
• 110567-21-0 (1S,2R)-2-(benzyloxymethyl)-1-hydroxy-3-cyclopentene 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 542-92-7 cyclopenta-1,3-diene 

Relevant articles and documents

Properties of oligonucleotide with phenyl-substituted carbocyclic nucleoside analogs for the formation of duplex and triplex DNA

(1S,3S,4R)-1-Phenyl-1-thymidyl-3-hydroxy-4-hydroxymethylcyclopentane (10) and their analogs were synthesized, incorporated into the oligodeoxynucleotides, and their properties were evaluated for the formation of duplex and triplex DNA. The known chiral cyclopentanone derivative was converted into the corresponding ketimine sulfonamide derivative, which was subjected to a stereoselective PhLi addition. The formed sulfonamide was hydrolyzed to afford the primary amino group, on which the thymine moiety was built. The benzyl protecting groups were removed to form the nucleoside analog having a phenyl group and the thymine unit at the 1 position of a carbocyclic skeleton (10). In the estimation of the oligodeoxynucleotides incorporating 10 for duplex and triplex formation, the carbocyclic nucleoside analog 10 did not show the stabilizing effect for duplex formation; on the other hand, it stabilized the triplex. Therefore, the skeleton of the phenyl-substituted carbocyclic nucleoside analog 10 may be a platform for the formation of stable triplex DNA.