1416988-31-2Relevant articles and documents
Design and synthesis of new N-substituted amino methyl-[1,2,3] triazolyl moieties of fluoroquinolones as antibacterial agents
Govinda Rajulu,Bhojya Naik, Halehatty S.,Viswanathan, Abhilash,Agarwal, Devesh S.,Sambasivam, Ganesh,Koppolu, Kesavan Poonimangadu
, p. 3843 - 3856 (2013/07/26)
A series of twenty new N-substituted amino methyl-[1,2,3] triazolyl derivatives at C-7 position of fluoroquinolones were designed and synthesized through multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI-MS, and IR. The antibacterial activities of these new fluoroquinolones were evaluated using a standard broth micro dilution technique. Out of the twenty derivatives, aryl substituted amino derivatives (6m to 6q) exhibited very good potency in inhibiting the growth of Methicillin-sensitive Staphylococcus aureus (MSSA), Methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococcus faecalis (VRE faecalis) (MIC: 0.25-4.00 μg/mL) as compared to the marketed drugs Linezolid and Ciprofloxacin.