1416988-51-6

Basic information

• Product Name: 1-cyclopropyl-6-fluoro-7-{4-[(4-fluoro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
• Synonyms: 1-cyclopropyl-6-fluoro-7-{4-[(4-fluoro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
• CAS NO: 1416988-51-6
• Molecular Weight: 465.459
• Mol File: 1416988-51-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-cyclopropyl-6-fluoro-7-{4-[(4-fluoro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-6-fluoro-7-{4-[(4-fluoro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester(1416988-51-6)
• EPA Substance Registry System: 1-cyclopropyl-6-fluoro-7-{4-[(4-fluoro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester(1416988-51-6)

Safety Data

• Hazardous Substances Data: 1416988-51-6(Hazardous Substances Data)

Upstream product

• 1416988-17-4 7-(4-chloromethyl-[1,2,3]triazol-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 371-40-4 4-fluoroaniline 
• 98349-25-8 ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 415965-23-0 7-azido-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 1416988-16-3 1-cyclopropyl-6-fluoro-7-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 1416988-31-2 1-cyclopropyl-6-fluoro-7-{4-[(4-fluoro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 

Relevant articles and documents

Design and synthesis of new N-substituted amino methyl-[1,2,3] triazolyl moieties of fluoroquinolones as antibacterial agents

A series of twenty new N-substituted amino methyl-[1,2,3] triazolyl derivatives at C-7 position of fluoroquinolones were designed and synthesized through multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI-MS, and IR. The antibacterial activities of these new fluoroquinolones were evaluated using a standard broth micro dilution technique. Out of the twenty derivatives, aryl substituted amino derivatives (6m to 6q) exhibited very good potency in inhibiting the growth of Methicillin-sensitive Staphylococcus aureus (MSSA), Methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococcus faecalis (VRE faecalis) (MIC: 0.25-4.00 μg/mL) as compared to the marketed drugs Linezolid and Ciprofloxacin.